1. A rollover Ir(III) complex of 2-(6-bromopyridin-2-yl)imidazo[1,2-a]pyridine.
- Author
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Varela, Yazmin, Ramírez-García, Gonzalo, Jimenez-Halla, J. Oscar C., Segovia-Mendoza, Mariana, Prado-Garcia, Heriberto, Wrobel, Katarzyna, Wrobel, Kazimierz, Gutiérrez-Granados, Silvia, Lemini, Cristina, and Serrano, Oracio
- Subjects
IMIDAZOPYRIDINES ,PYRIDINE ,DENSITY functional theory ,MASS spectrometry ,ABSORPTION spectra - Abstract
Here in, we report a rollover iridacycle complex cis-[Ir(κ
2 -C–N-L1 )(κ2 -N–N-L1 )Cl2 ], which can be easily obtained as yellow solid, through the reaction of two equivalents of new 2-(6-bromopyridin-2-yl)imidazo[1,2-a]pyridine (L1 ) type ligand and IrCl3 in dimethylformamide at 70 °C for a week. Rollover complex have an unusual κ2 -C–N-cyclometallated ligand fragment, which involves the C–H bond activation reaction in remote position on bromo-pyridine, with a second one in classic κ2 -N–N-donor mode. The structure of both compounds was studied by NMR, IR, and high-resolution mass spectrometry. Rollover complex UV/Vis absorption spectrum showed a dominating π–π* absorption band at 350 nm. Excitation at 385 nm gave a narrow emission band with maximum at 541 nm, which was associated to ligand-centred emission. The ligand shows antiproliferative activities against breast cancer lines. Density Functional Theory (DFT) calculations suggest that the rollover C–H bond activation occurs after a first κ2 -N–N coordination during the complexation of the second ligand and is supported by DMF molecules. [ABSTRACT FROM AUTHOR]- Published
- 2023
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