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A new water-soluble receptor 1 has been synthesized and it showed selective recognition of zwitterionic arginine in aqueous media. Moreover, the receptor 1 could be regard as a facile tool for protein labeling and quantitative determination (LOD = 15 nM).

Recently, the detection of amino acids has attracted considerable attention in the field of nutrition analysis, health monitoring, and medical diagnosis due to their significance for organisms. In this work, two novel Cd(II)-based metal–organic frameworks (MOFs) with the formulas [Cd(bib)2(SiF6)]n (1) and {[Cd(bib)2(SiF6)]·DMF·3H2O}n (2, bib = 1-(4-imidazol-1-ylphenyl)imidazole) were synthesized and exhibited fluorescence sensing capacity for arginine. In spite of having the same framework composition, complexes 1 and 2 showed great differences in their structure originating in the variations between the coordination modes of SiF62− with Cd2+ and the extension direction of the Cd-bib coordination complexes. Structural analysis manifested that complex 1 featured a 3D coordination framework constructed from 2D Cd-bib coordination layers bridged by SiF62− anions, while complex 2 possessed 3-fold interpenetrated Cd-bib coordination networks connected by SiF62− anions. Furthermore, fluorescence sensing experiments exhibited that both complexes 1 and 2 could be used as fluorescence probes for arginine and the emission intensities of complexes 1 and 2 could be enhanced up to 10.3 and 12.0 times that of the initial emission intensities upon the addition of Arg, respectively. [ABSTRACT FROM AUTHOR]