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Your search keyword '"Zhao, Lishuang"' showing total 2 results
Start Over Author "Zhao, Lishuang" Topic cancer cells Publisher royal society of chemistry
2 results on '"Zhao, Lishuang"'

1. Synthesis of novel isoindole-containing phakellistatin 2 analogs and the conformation features affecting their antitumor activities.

Author

Zhao, Lishuang, Wu, Jingwan, Bao, Yujun, Jiang, Shitian, Wang, Zhiqiang, Guo, Changhong, Jin, Yingxue, and Qu, Fengyu

Subjects
*ISOINDOLE, *INDOLE, *CANCER cells, *CELL membranes, *HANDEDNESS
Abstract

Two novel isoindole-doped cyclopeptide analogs of phakellistatin 2 with γ-turns were prepared. The compound with all D -Pro residues showed better antitumor activity against HepG-2 cells than that containing all L -Pro moieties, indicating the importance of the handedness of the conformation. LDH release tests showed that the compounds killed the cancer cells through a membrane disruption mechanism. [ABSTRACT FROM AUTHOR]

Published
2019
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2. Photo-induced synthesis of chiral galaxamide analogs and the biological activities against human tumor cells.

Author

Wu, Jingwan, Zhao, Lishuang, Wang, Zhiqiang, and Jin, Yingxue

Subjects
*AMIDE synthesis, *CANCER cells, *BIOACTIVE compounds
Abstract

Two novel chiral cyclic peptide analogues of galaxamide were synthesized by photoinduced single electron transfer cyclization. Their stereochemistry was studied by experimental and theoretical ECD simulations. The title compounds were found to be active against HepG-2 cell lines (IC50 = 19.52 for 1 and 26.34 μg mL−1 for 2). [ABSTRACT FROM AUTHOR]

Published
2018
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