1. Synthesis of tetronic acids from propargylic alcohols and CO2.
- Author
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Shen, Guo, Zhou, Wen-Jun, Zhang, Xiao-Bo, Cao, Guang-Mei, Zhang, Zhen, Ye, Jian-Heng, Liao, Li-Li, Li, Jing, and Yu, Da-Gang
- Subjects
TETRONIC acid ,PROPARGYL alcohol ,CARBON dioxide - Abstract
A direct and practical synthesis of important tetronic acids from easily available propargylic alcohols and carbon dioxide is reported for the first time. This transition-metal-free transformation features high atom- and step-economy, mild reaction conditions, good functional group tolerance and high yield. Preliminary mechanistic studies suggest that the reaction proceeds via cyclization to give alkylidene cyclic carbonate, ring-opening and re-cyclization processes. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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