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As a large group of chemicals with diverse properties, per- and polyfluoroalkyl substances (PFAS) have found extensive application throughout consumer products, including cosmetics. Little is known about the importance of dermal uptake as a human exposure pathway for PFAS. Here we investigate a suite of listed-ingredient and residual PFAS in cosmetic products, along with their dermal bioaccessibility using in vitro incubations with artificial sweat. Concentrations of volatile listed ingredients (including cyclic perfluorinated alkanes, perfluorinated ethers, and polyfluorinated silanes) in three products ranged from 876–1323 μg g−1, while polar listed ingredients (i.e., polyfluoroalkyl phosphate esters [PAPs]) in a single product occurred at up to 2427 μg g−1 (6 : 2/6 : 2 diPAP)). Residual perfluoroalkyl carboxylic acids (PFCAs) were also measured at concentrations ranging from 0.02–29 μg g−1. When listed ingredients were included, our targeted analysis accounted for up to 103% of the total fluorine, while highlighting ambiguous and/or incorrect International Nomenclature of Cosmetic Ingredient (INCI) names used in several products. Bioaccessibility experiments revealed that residual PFCAs readily partitioned to artificial sweat (bioaccessible fractions ranging from 43–76% for detectable substances) while listed ingredients (i.e., PAPs and neutral/volatile PFAS) displayed negligible partitioning. This work provides new insight into the occurrence of PFAS in cosmetic products, while furthering our understanding on their mechanisms of dermal uptake. [ABSTRACT FROM AUTHOR]

Polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), and hexabromocyclododecane (HBCDD) are regulated under the Stockholm Convention of the United Nations' Environment Programme; with similar concerns emerging about alternative halogenated flame retardants (alt-HFRs), the use of which is increasing as replacements for PBDEs and HBCDD. While the presence in indoor dust of PCBs, PBDEs, and HBCDDs has been reported previously in a few African locations including Lagos, Nigeria, we are unaware of similar data for alt-HFRs. The present study thus aimed to provide the first information on alt-HFRs in indoor dust in sub-Saharan Africa, and to evaluate the impact of restrictions on the use of PBDEs, HBCDD, and PCBs on their concentrations in house dust in Lagos, Nigeria. Concentrations of ∑8PBDEs, ∑HBCDDs, ∑7alt-HFRs, and ∑8PCBs in 15 samples of dust from homes in Lagos, Nigeria were found to be: 43–810 (median = 300) ng g−1,

−1, 32–2600 (median = 320) ng g−1 and 3.8–61 (median = 18) ng g−1 respectively. The dominant PBDE was BDE-209, its replacement decabromodiphenyl ethane (DBDPE) was the predominant alt-HFR, while PCB-138 displayed the highest concentration of the 8 PCBs targeted. Likely due to their higher vapour pressures, concentrations of the non-arochlor PCB 11, as well as those of PCB 28, and PBDE 28 were below detection limits. Concentrations of PBDEs and PCBs reported are generally below those reported previously for Lagos, Nigeria; suggesting restrictions on their manufacture and use have been effective. In contrast, while concentrations of BDE-209 in this study were lower than in one previous study in Lagos, they exceeded those in another; implying that the more recent restrictions on the deca-BDE product have yet to be fully effective. The evidence presented here of concentrations of alt-HFRs in Nigerian house dust provide a valuable benchmark against which future trends in their concentrations may be evaluated. [ABSTRACT FROM AUTHOR]

Surface riverine sediment samples were collected along the course of the River Medway, UK, between Yalding and the mouth of the estuary at 40 different sites. The samples were then analysed for hexabromocyclododecane (HBCDD) concentrations using a liquid chromatography system coupled to a high-resolution, accurate mass Orbitrap™ mass spectrometer. After normalisation to the sediment organic carbon (OC) content, average ΣHBCDD was 270 ng g−1 OC with a maximum concentration of 1006 ng g−1 OC. Spatial trend analysis revealed that industrial and residential land uses have significantly influenced HBCDD concentrations and profiles in riverine sediments. Higher concentrations of ΣHBCDD were found in sites near construction and maritime port locations, and these included freight ports, new builds and demolition sites. The HBCDD isomer profile reflected that of the commercial mixture with a comparatively high γ-HBCDD to α-HBCDD and β-HBCDD. The isomer profiles of sites located near construction activities indicate recent pollution events, with increased γ-HBCDD and decreased α-HBCDD compared to the study area's average profile. HBCDD isomer concentrations also indicated that the non-tidal portions of the river caused by locks showed a profile that was typical of older HBCDD contamination, indicating a possible sediment and HBCDD trap. [ABSTRACT FROM AUTHOR]

An in vitro colon extended physiologically based extraction test (CEPBET) which incorporates human gastrointestinal tract (GIT) parameters (including pH and chemistry, solid-to-fluid ratio, mixing and emptying rates) was applied for the first time to study the bioaccessibility of brominated flame retardants (BFRs) from the 3 main GIT compartments (stomach, small intestine and colon) following ingestion of indoor dust. Results revealed the bioaccessibility of γ-HBCD (72%) was less than that for α- and β-isomers (92% and 80% respectively) which may be attributed to the lower aqueous solubility of the γ-isomer (2 μg L−1) compared to the α- and β-isomers (45 and 15 μg L−1 respectively). No significant change in the enantiomeric fractions of HBCDs was observed in any of the studied samples. However, this does not completely exclude the possibility of in vivo enantioselective absorption of HBCDs, as the GIT cell lining and bacterial flora – which may act enantioselectively – are not included in the current CE-PBET model. While TBBP-A was almost completely (94%) bioaccessible, BDE-209 was the least (14%) bioaccessible of the studied BFRs. Bioaccessibility of tri-hepta BDEs ranged from 32–58%. No decrease in the bioaccessibility with increasing level of bromination was observed in the studied PBDEs. [ABSTRACT FROM AUTHOR]