1. N-Sulfonylation of azoles with sulfonyl hydrazides enabled by electrocatalysis.
- Author
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Huang, Cheng, Kang, Chen, Liu, Hong-Jun, Wang, Chen-Lu, Tang, Sheng, Qin, Yu-Shu, Wei, Zhenhong, and Cai, Hu
- Subjects
EINSTEIN-Podolsky-Rosen experiment ,COMPLEX compounds ,BIOCHEMICAL substrates ,HYDRAZIDES ,ELECTROCATALYSIS - Abstract
Reported herein is an electrochemical strategy for N-sulfonylation of azoles with sulfonyl hydrazides, offering efficient access to valuable N-sulfonated azoles. Organic radical species were involved in the process and EPR experiments provided evidence for the formation of intermediates in situ. The electrochemical reaction features metal-free, mild conditions, and a broad substrate scope (>70 examples). The gram-scale synthesis via an electrochemical continuous-flow reaction and late-stage modification of complex compounds is advocated for its practical value. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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