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Your search keyword '"Roger Alberto"' showing total 8 results
Start Over Author "Roger Alberto" Publisher royal society of chemistry
8 results on '"Roger Alberto"'

1. A novel 99mTc labelling strategy for the development of silica based particles for medical applications

Author

Michel A. Wuillemin, Michael J. Reber, Henrik Braband, Roger Alberto, Thomas Fox, Wanda T. Stuber, Dominik Brühwiler, University of Zurich, and Braband, Henrik

Subjects
Models, Molecular, 10120 Department of Chemistry, Materials science, Mesoporous, Alkenes, Inorganic Chemistry, Reaction rate, chemistry.chemical_compound, Labelling, 540 Chemistry, Humans, Organic chemistry, Radioimaging, Norbornene, Cycloaddition Reaction, 1604 Inorganic Chemistry, Technetium, Stereoisomerism, Silica, Organotechnetium Compounds, Mesoporous silica, Silicon Dioxide, Norbornanes, Combinatorial chemistry, 540: Chemie, 610: Medizin und Gesundheit, chemistry, Radiopharmaceuticals, Mesoporous material
Abstract

The reaction of high-valent fac-{(99m)TcO3}(+) complexes with alkenes ((3 + 2)-cycloaddition) has been used to develop a novel labelling procedure for silica based particles. This strategy can help to gain more detailed in vivo data of mesoporous silica by non-invasive radioimaging in the future. By applying norbornene as a coupling unit the (3 + 2)-cycloaddition reaction proceeds stereoselectively and with high reaction rates.

Published
2014

2. Acyloxybutadiene tricarbonyl iron complexes as enzyme-triggered CO-releasing molecules (ET-CORMs): a structure-activity relationship study

Author

Steffen Romanski, Andreas Adler, Sabine Amslinger, Miguel Guttentag, Hans-Günther Schmalz, Jörg-Martin Neudörfl, Waldemar Schlundt, Hannelore Rücker, Roger Alberto, Birgit Kraus, University of Zurich, and Amslinger, Sabine

Subjects
10120 Department of Chemistry, Models, Molecular, Cell Survival, Stereochemistry, ddc:540, Substituent, Nitric Oxide Synthase Type II, Crystallography, X-Ray, Nitric Oxide, Inorganic Chemistry, Mice, Structure-Activity Relationship, chemistry.chemical_compound, 540 Chemistry, Animals, Structure–activity relationship, Molecule, Enzyme Inhibitors, Cytotoxicity, Cells, Cultured, chemistry.chemical_classification, Dose-Response Relationship, Drug, Molecular Structure, 1604 Inorganic Chemistry, Cellular Assay, Enzyme, chemistry, Myoglobin, 540 Chemie, Single crystal, Iron Compounds
Abstract

A series of η(4)-acyloxycyclohexadiene-Fe(CO)(3) complexes was prepared and fully characterized by spectroscopic methods including single crystal X-ray diffraction. For this purpose a new synthetic access to differently acylated 1,3- and 1,5-dienol-Fe(CO)(3) complexes was developed. The enzymatically triggered CO release from these compounds was monitored (detection of CO through GC and/or by means of a myoglobin assay) and the anti-inflammatory effect of the compounds was assessed by a cellular assay based on the inhibition of NO-production by inducible NO synthase (iNOS). It was demonstrated that the properties (rate of esterase-triggered CO release, iNOS inhibition, cytotoxicity) of the complexes strongly depend on the substitution pattern of the π-ligand and the nature of the acyloxy substituent.

Published
2012

3. Substitution reactions with [ReBr2(CO)2(NCCH3)2]−: a convenient route to complexes with the cis-[Re(CO)2]+ core.

Author

Lukas Kromer, Bernhard Spingler, and Roger Alberto

Subjects
LINE geometry, LINEAR algebra, MATHEMATICAL complexes, SYMPLECTIC spaces
Abstract

Water- and air-stable complexes comprising the cis-[Re(CO)2]+ core can be synthesized from the (Et4N)[ReBr2(NCCH3)2(CO)2] precursor 1. Complex 1 showed distinctly different chemical and electronic behaviour compared to [ReBr3(CO)3]2−. Substituting the two bromides in 1 with imidazole-like ligands or α,α’-diimines gave new complexes with potential applications in bioinorganic chemistry and photochemistry. The two acetonitrile ligands are very stably bound and could not be replaced. Under CO pressure, the uncommon complex mer-[ReBr(NCCH3)2(CO)3] 2 was formed from 1. The reaction of 1 with the tetradentate ligand bis(2-pyridylmethyl)glycine (BPG) finally induced a four fold substitution at the metal center to form a [Re(CO)2(L4)]+-type complex. [ABSTRACT FROM AUTHOR]

Published
2008
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4. Syntheses of a series of S6 thioether cages and their coordination chemistry with Ag+.

Author

Roger Alberto, Daniela Angst, Kirstin Ortner, Ulrich Abram, P. August Schubiger, and Thomas A. Kaden

Subjects
*RADIOIMMUNOTHERAPY, *SILVER, *CRYSTALS, *COORDINATION compounds
Abstract

The syntheses of four S6-cages with different cavity sizes are described. In regard of potential applications for radioimmunotherapy with 111Ag, their coordination behaviour towards Ag(i) was evaluated by studies of their reactivity in solution and of their crystal structures. All cages reacted differently with Ag(i). Whereas S6-cages based on 3,8,12,17,20,25-hexathiabicyclo[8.8.8]-hexacosane (14) and on 5,9,17,21,28,31-hexathiabicyclo[11.11.11]pentatriacontane (18) showed only external Ag(i) coordination, successive adaptation of the cage size, yielded ligand 24, based on 4,7,13,21,24,25-hexathiabicyclo[8.8.8]hexacosane, which gave a complex with internal-peripheral Ag(i) binding. [ABSTRACT FROM AUTHOR]

Published
2007
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7. Ligand-mediated decarbonylation as an efficient synthetic method to Re(i) and Re(ii) dicarbonyl complexes.

Author

Fabio Zobi, Bernhard Spingler, and Roger Alberto

Subjects
MATHEMATICAL transformations, ALGORITHMS, DIFFERENTIAL invariants, DIFFERENTIAL geometry
Abstract

A novel synthetic method based on a ligand-mediated decarbonylation reaction of complexes of the common fac-[Re(CO)3]+ core efficiently yields Re(i) and Re(ii) dicarbonyl species. [ABSTRACT FROM AUTHOR]

Published
2008
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