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Low levels of immune infiltrates in the tumor milieu hinder the effectiveness of immunotherapy against immune-cold tumors. In the current work, a tumor-targeting drug delivery system composed of Endo-loaded platelets (Endo@PLT) was developed to relieve immunosuppression by achieving tumor vascular normalization. Endo@PLT reprogrammed the immunostimulatory phenotype, achieving excellent PD-1 immunotherapy in vivo. [ABSTRACT FROM AUTHOR]

A high voltage (1.38 V) total organic aqueous redox flow battery is reported using 1,1′-bis[3-(trimethylammonio)propyl]-4,4′-bipyridinium tetrachloride ((NPr)2V) as an anolyte and 4-trimethylammonium-TEMPO chloride (NMe-TEMPO) as a catholyte. The exceptional radical stability of [(NPr)2V]+Ṗ enabled the flow battery in achieving 97.48% capacity retention for 500 cycles and a power density of 128.2 mW cm−2. [ABSTRACT FROM AUTHOR]

Mononuclear non-heme iron enzymes are a large class of enzymes catalyzing a wide-range of reactions. In this work, we report that a non-heme iron enzyme in Methyloversatilis thermotolerans , OvoA Mtht, has two different activities, as a thiol oxygenase and a sulfoxide synthase. When cysteine is presented as the only substrate, OvoA Mtht is a thiol oxygenase. In the presence of both histidine and cysteine as substrates, OvoA Mtht catalyzes the oxidative coupling between histidine and cysteine (a sulfoxide synthase). Additionally, we demonstrate that both substrates and the active site iron's secondary coordination shell residues exert exquisite control over the dual activities of OvoA Mtht (sulfoxide synthase vs. thiol oxygenase activities). OvoA Mtht is an excellent system for future detailed mechanistic investigation on how metal ligands and secondary coordination shell residues fine-tune the iron-center electronic properties to achieve different reactivities., Competing Interests: There are no conflicts to declare., (This journal is © The Royal Society of Chemistry.)