1. One-pot hydrothermal synthesis of fluorophore-modified cerium oxide nanoparticles.
- Author
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Tsyupka, Daria V., Pigarev, Sergey V., Podkolodnaya, Yuliya A., Khudina, Ekaterina A., Popova, Nelli R., Goryacheva, Irina Yu., and Goryacheva, Olga A.
- Abstract
Cerium oxide nanoparticles (CeO
2 NPs), which have powerful antioxidant properties, are promising nanomaterials for the treatment of diseases associated with oxidative stress. The well-developed surface of CeO2 NPs makes them promising for use as a multifunctional system for various biomedical applications. This work demonstrates a simple approach that allows the direct formation of a molecular fluorophore on the surface of CeO2 NPs using a simple one-pot hydrothermal synthesis. Thus, we were able to synthesize CeO2 NPs of ultra-small size ∼2 nm with a narrow distribution, highly stable fluorescence, and a quantum yield of ∼62%. UV-visible transmission studies revealed that the resulting CeO2 NPs exhibited fast autogenerative catalytic reduction. In vitro results showed high biocompatibility of CeO2 NPs; their internalization occurs mainly in the region of cell nuclei. Thus, the resulting NPs have the necessary parameters and can be successfully used in biovisualization and therapy. [ABSTRACT FROM AUTHOR]- Published
- 2024
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