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Examples of Fischer's base-triggered (3+2) cycloadditions and expanding the applicability scope of 3-isothiocyanato oxindoles.

This is the first example of the construction of harmaline-based spiropolycyclic scaffolds using harmaline-based N–C synthons and evaluation of 3cb as an anticancer agent.

This is the combination of three key pharmacophores through bispiro quaternary carbon atoms and evaluation of their anticancer activity.

We present a novel highly stereoselective Rh-catalyzed cyclopropanation of diazothiooxindoles with a broad range of α-functionalized styrenes, enabling facile access of chiral spirocyclopropylthiooxindoles in high to excellent enantiomeric excess.

The first example of the introduction of a spiroindanedione moiety into a spirobutyrolactone framework.

Herein a previously unreported trimethylindolenines serving as useful C-N synthons in [3+2] cycloaddition reactions of donor-acceptor 3-isothiocyanato oxindoles to build a library of spiro[oxindole-thioxoimidazolidine-indoline] hybrids is described. A wide range...

This review summarizes the advances in catalytic enantioselective reactions using CO2 as a C1 synthon, introduces major synthetic strategies and discusses their advantages and limitations, highlights the application of known protocols, and outlines the synthetic opportunities.

This review summarizes the advances in the catalytic enantioselective construction of vicinal quaternary carbon stereocenters, introduces major synthetic strategies and discusses their advantages and limitations, highlights the application of known protocols in the total synthesis of natural products, and outlines the synthetic opportunities., This review summarizes the advances in catalytic enantioselective construction of vicinal quaternary carbon stereocenters, introduces major synthetic strategies and discusses their advantages and limitations, and outlines the synthetic opportunities.