1. Acutely administered grape-seed proanthocyanidin extract acts as a satiating agent
- Author
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Ximena Terra, Montserrat Pinent, Katherine Gil-Cardoso, Anna Ardévol, Joan Serrano, Àngela Casanova-Martí, and M. Teresa Blay
- Subjects
Male ,0301 basic medicine ,food.ingredient ,Body weight ,Satiety Response ,Eating ,Random Allocation ,03 medical and health sciences ,food ,Animals ,Proanthocyanidins ,Food science ,Rats, Wistar ,Gastrointestinal tract ,Cross-Over Studies ,030109 nutrition & dietetics ,Grape Seed Extract ,Gastric emptying ,Chemistry ,Cocoa Extract ,Body Weight ,digestive, oral, and skin physiology ,food and beverages ,General Medicine ,Crossover study ,Rats ,Gene Expression Regulation ,Proanthocyanidin ,Grape seed extract ,Grape seed proanthocyanidin ,Female ,Food Science - Abstract
Grape-seed proanthocyanidins' role as stimulators of active GLP-1 in rats suggests that they could be effective as satiating agents. Wistar rats were used to study the effects of proanthocyanidins on food intake with different doses, administration times and proanthocyanidin extract compositions. A dose of 423 mg of phenolics per kg body weight (BW) of grape-seed proanthocyanidin extract (GSPE) was necessary to decrease the 12-hour cumulative food intake by 18.7 ± 3.4%. Proanthocyanidins were effective when delivered directly into the gastrointestinal tract one hour before, or simultaneously at the start of the feeding period. Proanthocyanidins without galloyl forms, such as those from cocoa extract, were not as effective as grape-seed derived forms. GSPE increased the portal levels of active GLP-1 and total ghrelin and decreased the CCK levels, simultaneously with a decrease in gastric emptying. In conclusion, grape-seed proanthocyanidins could be useful as a satiating agent under the conditions defined in this study.
- Published
- 2016
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