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Start Over Author "Matthew G. Lloyd" Publisher royal society of chemistry (rsc)
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1. A selective C–H insertion/olefination protocol for the synthesis of α-methylene-γ-butyrolactone natural products

Author

Richard J. K. Taylor, Mariantonietta D'Acunto, William P. Unsworth, and Matthew G. Lloyd

Subjects
Biological Products, Natural product, Molecular Structure, 010405 organic chemistry, Stereochemistry, Organic Chemistry, Late stage, α methylene γ butyrolactone, Total synthesis, Stereoisomerism, 010402 general chemistry, 01 natural sciences, Biochemistry, 0104 chemical sciences, chemistry.chemical_compound, 4-Butyrolactone, chemistry, Stereoselectivity, Physical and Theoretical Chemistry
Abstract

A regio- and stereoselective one-pot C-H insertion/olefination protocol has been developed for the late stage installation of α-methylene-γ-butyrolactones into conformationally restricted cyclohexanol-derivatives. The method has been successfully applied in the total synthesis of eudesmanolide natural product frameworks, including α-cyclocostunolide.

Published
2016
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