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Although many semiconductor heterojunctions have been prepared to promote radiation-generated exciton separation for radiocatalysis therapy (RCT), most of them inevitably sacrifice the redox ability of radiation-generated electrons and holes. Herein, we design and construct BiOI/Bi

The exploration of two-leg spin-ladder materials is a great challenge to the chemical community since it is one of the most ideal models for the study of low-dimensional magnetism and high-Tc superconductivity. Herein, we report on a successful synthesis of a new Cu2+-based two-leg ladder compound constructed by CuO4Cl2 octahedra along the [101] direction. The magnetic results exhibit a broad peak at Tmax ∼ 265 K, and suggest that CdCu2(SeO3)2Cl2 has a spin singlet ground state. The fitting of the isolated two-leg spin-ladder model shows J⊥/kB = 429 K and J‖/kB = 21 K, leading to a large spin gap of ∼409 K.

A new selenite compound CaNi2(SeO3)3·2H2O (1) was obtained by a conventional hydrothermal method, featuring a distorted zemannite-type structure with a unique honeycomb-like hexagonal framework. The crystal-to-crystal transformation from 1 to a partially dehydrated form of CaNi2(SeO3)3·1.5H2O (2) with slightly shrunk hexagonal framework and further to an anhydrous CaNi2(SeO3)3 (3) with a square framework can be achieved by step-by-step dehydration under heating. The UV-vis-NIR absorption spectra indicate that all 1–3 to possess a wide band gap due to spin allowed d–d transition at Ni2+ ion centers. Further, magnetic measurements show a similar magnetic behavior with an antiferromagnetic transition in 1 and 2, while a different magnetic behavior with two magnetic transitions is observed in 3.

Two new selenite compounds Ca2Ni(HSeO3)2(SeO3)2 (CaNi) and Na2Cu(SeO3)2·2H2O (NaCu) were obtained by a hydrothermal method. Both compounds crystallize in the triclinic system of space group P1, featuring a selenite-bridged one-dimensional (1D) spin-chain structure running along the a-axis. Magnetic measurements indicate that CaNi undergoes a long-range antiferromagnetic order (LRO) at TN = ∼3.8 K, while NaCu does not exhibit a LRO down to 2 K but the onset of a short-range correlation at TM = ∼30 K. The intrachain exchange coupling J/kB = -2.59 K for CaNi and J/kB = -47.13 K for NaCu can be estimated by a fit using the 1D spin-chain model. The thermogravimetric analyses show that both compounds are stable below 130 °C. The UV-vis diffuse reflectance spectra indicate that the band gaps of CaNi and NaCu are 4.38 eV and 3.18 eV, respectively.

Cyclic ethers are important scaffolds employed in the synthesis of various natural products and pharmaceutical ingredients. A novel free radical-initiated reaction between cyclic ethers and maleimide iodides through C-H activation is developed, avoiding the use of transition metallic catalysts. This method provides a simple approach to derive cyclic ethers, which were further applied in various cross coupling reactions.

Bladder cancer is a common urinary tract tumor in clinic, and its morbidity and mortality are always high. Surgical treatment is operator dependent, residual tumor cells often lead to tumor recurrence, and chemotherapy after surgery causes high side effects. So, it is urgent to develop new methods for the theranostics of bladder cancer. Among them, functional nanomaterials have shown good application in tumor theranostics, but they are rarely used in bladder cancer. In our work, we demonstrate the fabrication of folate-modified vincristine-loaded polydopamine-coated Fe3O4 superparticles (Fe3O4@PDA-VCR-FA SPs), and applied them in the theranostics of bladder cancer. The PDA shell not only improves the colloidal stability and biocompatibility, but also enhances the photothermal effect and prolongs the blood circulation half-life. The half-life of Fe3O4@PDA-VCR-FA SPs in blood is calculated as 2.83 h, and the tumor retention rate is 5.96 %ID g-1, these data are significantly higher than those before folic acid modification. The superparamagnetism of Fe3O4 and loading of vincristine endow Fe3O4@PDA-VCR-FA SPs with magnetic resonance imaging and chemotherapy capabilities. Further by employing NIR laser-triggered photothermal therapy, bladder tumors were ablated completely, and no recurrence was observed. Blood and histological tests of the major organs confirm that Fe3O4@PDA-VCR-FA SPs show good biosafety.

Enyne-allene compounds undergo Myers-Saito cyclization at physiological temperature to generate diradical intermediates that are capable of inducing DNA damage and cell death. The high reactivity of enyne-allene however limits their promising prospect as anticancer agents due to the spontaneous cyclization during storage and delivery. Regulating the cyclization process by taking advantage of the characteristics of a tumor cellular microenvironment, such as employing a low pH value to activate the cyclization process, is thus of essential importance. In this work, a novel enediyne (EDY) system with locked carbonyl groups was specifically designed and synthesized. Unlocking the protected carbonyl groups in the presence of acid would facilitate the rearrangement of propargyl moieties into an allene group, enabling the formation of an enyne-allene structure and occurrence of Myers-Saito cyclization. The pH-dependent diradical generation and DNA-cleavage ability of the designed EDY system were confirmed by electron paramagnetic resonance analysis and DNA gel electrophoresis. A promising cytotoxicity against HeLa cells with half inhibition concentrations (IC50) as low as 1.40 μM was obtained, which was comparable to those of many commercially applied anticancer drugs. Further in vitro experiments revealed that this EDY system induced intracellular DNA damage and subsequently resulted in S-phase arrest and cytotoxicity through programmed apoptosis.

The Cu2+-based breathing kagome material Pb(OF)Cu3(SeO3)2(NO3) with both corner-sharing and edge-sharing has been synthesized. Magnetic measurements suggest ferromagnetic interactions inside the layers and antiferromagnetic interactions between the neighboring layers, leading to an antiferromagnetic ground state with a field-induced spin-flip transition at low temperature.

Three dodecanuclear 3d–4f coordination clusters, [CrIII6LnIII6(μ3-OH)8(tbdea)6(C6H5COO)16]·2H2O (Ln = Dy (1), Y (2)) and [CoIII6DyIII6(μ3-OH)8(nbdea)6(m-CH3C6H4COO)16]·2H2O·2CH3CN (3), have been synthesized under solvothermal conditions and characterized. Single-crystal X-ray diffraction analysis revealed that all three compounds possess an analogous {MIII6LnIII6} core (M = Cr, Co; Ln = Dy, Y) and dc magnetic susceptibility studies indicated that the magnetic exchange couplings between DyIII ions are dominant antiferromagnetic, while the CrIII–DyIII interactions are weakly ferromagnetic. Furthermore, the ac magnetic susceptibility measurements showed that both CrIII6DyIII6 compound 1 and CoIIi6DyIII6 compound 3 containing highly anisotropic DyIII ions displayed single-molecule magnetic (SMM) behavior with the energy barrier Ueff increasing from 12.8 K (for 1) to 20.8 K (for 3), indicating that weak 3d–4f exchange couplings enhance the QTM and reduce the energy barrier.