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Start Over Author "Shiru Yuan" Publisher royal society of chemistry (rsc)
1 results on '"Shiru Yuan"'

1. Enantioselective [2+2] annulation of simple aldehydes with isatin-derived ketimines via oxidative N-heterocyclic carbene catalysis

Author

Hongjun Ren, Shiru Yuan, Jingyi Peng, Maozhong Miao, Zhengkai Chen, and Jianfeng Xu

Subjects
Annulation, 010405 organic chemistry, Isatin, Metals and Alloys, Enantioselective synthesis, General Chemistry, 010402 general chemistry, 01 natural sciences, Combinatorial chemistry, Catalysis, 0104 chemical sciences, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Stereocenter, chemistry.chemical_compound, chemistry, Intramolecular force, Materials Chemistry, Ceramics and Composites, Organic chemistry, Stereoselectivity, Carbene, Mannich reaction
Abstract

An asymmetric [2+2] annulation reaction through direct α-carbon functionalization of simple aldehydes via oxidative N-heterocyclic carbene catalysis is disclosed. These in situ generated triazolium enolate intermediates undergo a highly stereoselective Mannich reaction with isatin-derived ketimines followed by intramolecular lactamization to afford enantioenriched spirooxindole β-lactams bearing two vicinal stereogenic centers.

Published
2017

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