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The development of a versatile new one pot, catalyst free, multicomponent-tandem strategy for assembly of spirooxindole-indazolones and spirooxindole-pyrazolines is described. The reported protocol includes several advantages like environmental friendliness, cost effectiveness, high atom economy, short reaction times and high yields. The reported method is the first green synthesis of spirooxindole-indazolones and spirooxindole-pyrazolines.

A series of novel dihydropyrrolo[2,1-a]isoquinolines and dihydropyrrolo[1,2-a]quinolines have been synthesized from isoquinolines/quinolines, various substituted phenacyl bromides and substituted dialkylacetylenedicarboxylates via [3+2] cycloaddition reaction. The reaction proceeds in aqueous micellar medium with DBU as a catalyst. The present protocol offers a simple one pot sequential reaction affording products in excellent yields.

Oxa-aza-phenanthrene and anthracene derivatives which contain a bridgehead nitrogen are synthesized in an aqueous micellar system. The synthetic route is easy and yield is excellent. In this proposed method, solvent, base and surfactant are optimized and the best result was obtained by DBU in water with surfactant CTAB. All synthesized molecules are new. This method is an efficient, viable and sequential one pot synthetic route for the construction of desired product.

Diethyl sodiomalonate reacts readily with 8,8′-bisbromomethyl-1,1′-binaphthyl to form a nine-membered carbocyclic ring: this behaviour is similar to the reactions of diethyl sodiomalonate with 2,2′-bisbromomethylbiphenyl to form a seven-membered ring, and with o-xylylene dibromide to form a five-membered ring. The preparation of diethyl 8,9-dihydro-7H-cyclonona[1,2,3-de:4,5,6-d′e′]dinaphthalene-8,8-dicarboxylate, in the racemic and in the optically active state, and of derived substances, is described.

Determination of the absolute configuration of 1,1′-binaphthyls by the use of Cotton effects associated with the short wave band of the electronic absorption spectra is discussed and applied to examples with substituents in the 8- and 8′-positions. Racemisation parameters are determined for 1,1′-binaphthyl-8,8′-diacetic acid in 0·1N-aqueous sodium hydroxide solution.