113 results on '"Spring, David R."'
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2. Red-light modulated ortho-chloro azobenzene photoswitch for peptide stapling via aromatic substitution
3. A Recombinant Approach For Stapled Peptide Discovery Yields Inhibitors of the RAD51 Recombinase
4. Identification of macrocyclic peptides which activate bacterial cylindrical proteases
5. Synthesis of sp3-rich heterocyclic frameworks by a divergent synthesis strategy
6. Peroxide-cleavable linkers for antibody–drug conjugates
7. Disulfide re-bridging reagents for single-payload antibody-drug conjugates
8. A cell-active peptide targeting the Nrf2/Keap1 protein-protein interaction
9. Divinylpyrimidine reagents generate antibody-drug conjugates with excellent in vivo efficacy and tolerability
10. Rapid and robust cysteine bioconjugation with vinylheteroarenes
11. Antibody dual-functionalisation enabled through a modular divinylpyrimidine disulfide rebridging strategy
12. Non-internalising antibody–drug conjugates
13. Divinylpyrimidine reagents generate antibody–drug conjugates with excellent in vivo efficacy and tolerability
14. All-in-one disulfide bridging enables the generation of antibody conjugates with modular cargo loading
15. Development of small cyclic peptides targeting the CK2α/β interface
16. Correction: The multifaceted nature of antimicrobial peptides: current synthetic chemistry approaches and future directions
17. A fragment-based approach leading to the discovery of inhibitors of CK2α with a novel mechanism of action
18. Peptides as a platform for targeted therapeutics for cancer: peptide–drug conjugates (PDCs)
19. Site-selective modification strategies in antibody–drug conjugates
20. Chemical probes targeting the kinase CK2: a journey outside the catalytic box
21. The multifaceted nature of antimicrobial peptides: current synthetic chemistry approaches and future directions
22. The role of chemical synthesis in developing RiPP antibiotics
23. Rapid and robust cysteine bioconjugation with vinylheteroarenes
24. A dual-enzyme cleavable linker for antibody–drug conjugates
25. Photocatalytic methods for amino acid modification
26. Efficient and selective antibody modification with functionalised divinyltriazines
27. Demonstration of the utility of DOS-derived fragment libraries for rapid hit derivatisation in a multidirectional fashion
28. Sulfatase-cleavable linkers for antibody-drug conjugates
29. General dual functionalisation of biomacromolecules via a cysteine bridging strategy
30. Diarylethene moiety as an enthalpy-entropy switch: photoisomerizable stapled peptides for modulating p53/MDM2 interaction
31. Fsp3-rich and diverse fragments inspired by natural products as a collection to enhance fragment-based drug discovery
32. Total synthesis and biological evaluation of simplified aplyronine analogues as synthetically tractable anticancer agents
33. An efficient, stereocontrolled and versatile synthetic route to bicyclic partially saturated privileged scaffolds
34. C(sp3)–H arylation to construct all-syn cyclobutane-based heterobicyclic systems: a novel fragment collection
35. Stapled peptides as a new technology to investigate protein-protein interactions in human platelets
36. Second-generation CK2α inhibitors targeting the αD pocket
37. Correction: A general approach for the site-selective modification of native proteins, enabling the generation of stable and functional antibody–drug conjugates
38. Macrocyclisation and functionalisation of unprotected peptides via divinyltriazine cysteine stapling
39. Computationally-guided optimization of small-molecule inhibitors of the Aurora A kinase-TPX2 protein-protein interaction
40. Stereocontrolled semi-syntheses of deguelin and tephrosin
41. Cleavable linkers in antibody–drug conjugates
42. Water-soluble, stable and azide-reactive strained dialkynes for biocompatible double strain-promoted click chemistry
43. A general approach for the site-selective modification of native proteins, enabling the generation of stable and functional antibody–drug conjugates
44. Targeted covalent inhibitors of MDM2 using electrophile-bearing stapled peptides
45. Macrocyclisation and functionalisation of unprotected peptides via divinyltriazine cysteine stapling
46. Efficient development of stable and highly functionalised peptides targeting the CK2α/CK2β protein–protein interaction
47. Semi-syntheses of the 11-hydroxyrotenoids sumatrol and villosinol
48. Highly reactive bis-cyclooctyne-modified diarylethene for SPAAC-mediated cross-linking
49. Stapled peptides as a new technology to investigate protein–protein interactions in human platelets
50. Second-generation CK2α inhibitors targeting the αD pocket
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