1. Experimental study of the protective effect of mesosilica-supported 5-hydroxymethylfurfural on UV-induced aging of human dermal fibroblasts
- Author
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Yunyun Quan, Xueming Niu, Kun Wei, Zhenyu Wang, and Long Zhang
- Subjects
Thermogravimetric analysis ,Biocompatibility ,Diffuse reflectance infrared fourier transform ,Carrier system ,Chemistry ,General Chemical Engineering ,02 engineering and technology ,General Chemistry ,Mesoporous silica ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,Dynamic light scattering ,Drug delivery ,Fourier transform infrared spectroscopy ,0210 nano-technology ,Nuclear chemistry - Abstract
The drug 5-HMF (5-hydroxymethylfurfural, C6H6O3) is extensively studied for its antioxidative and anti-inflammatory properties. However, its unstable properties and biotoxicity restrict its use in skin care products and therapy. The present study was aimed at evaluating the potential of three-dimensional dendritic mesoporous silica nanospheres (3D-dendritic MSNs) as a topical carrier system for 5-HMF delivery. The encapsulation of the carrier also enhances the stability of the drug. Based on the results of Brunauer–Emmet–Teller (BET) analysis, Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), thermogravimetric analysis (TGA), dynamic light scattering (DLS), and UV-vis diffuse reflectance spectroscopy, drug delivery systems were successfully fabricated and the loading capacity (LC%) and entrapment efficiency (EE%) were also assessed. In vitro cell tests revealed the outstanding biocompatibility and inoxidizability of 3D-dendritic MSNs. There is no effect on the antioxidant properties of the drug. Therefore, mesoporous silica can be combined with 5-HMF and used as potential antioxidant medicine in cosmetic applications.
- Published
- 2018
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