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A facile and straightforward approach for the construction of amides via redox-neutral Ru-catalyzed cross-coupling reaction of long-range alkenyl alcohols with amines to realize remote site-selective functionalization has been developed.

A facile and straightforward synthetic method for the construction of amides via redox-neutral Ni/NHC-catalyzed dehydrogenative cross-coupling of alcohols and amines has been developed.

We present herein highly effective nickel-catalyzed Larock annulations of substituted 2-formylphenyl trifluoromethanesulfonate with alkynes to provide an access to a wide range of indenones that are valuable synthetic intermediates for natural compounds. This catalytic system is shown to proceed through a redox neutral arylation to produce indenone products in high yields with excellent regioselectivities. In addition, a highly efficient transformation of the natural product estrone via Ni-catalyzed Larock annulation can also be achieved.