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2 results on '"Musnier B"'

1. Surface functionalization of gold nanoclusters with arginine: a trade-off between microtumor uptake and radiotherapy enhancement.

Author

Broekgaarden M, Bulin AL, Porret E, Musnier B, Chovelon B, Ravelet C, Sancey L, Elleaume H, Hainaut P, Coll JL, and Le Guével X

Subjects
Cell Line, Humans, Neoplasms metabolism, Neoplasms pathology, Gold chemistry, Gold pharmacokinetics, Gold pharmacology, Metal Nanoparticles chemistry, Metal Nanoparticles therapeutic use, Neoplasms radiotherapy, Radiation-Sensitizing Agents chemistry, Radiation-Sensitizing Agents pharmacokinetics, Radiation-Sensitizing Agents pharmacology
Abstract

Ultra-small gold nanoclusters (AuNCs) are increasingly investigated for cancer imaging and radiotherapy enhancement. While fine-tuning the AuNC surface chemistry can optimize their pharmacokinetics, its effects on radiotherapy enhancement remain largely unexplored. This study demonstrates that optimizing the surface chemistry of AuNCs for increased tumor uptake can significantly affect its potential to augment radiotherapy outcomes.

Published
2020
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2. High photoluminescence of shortwave infrared-emitting anisotropic surface charged gold nanoclusters.

Author

Musnier B, Wegner KD, Comby-Zerbino C, Trouillet V, Jourdan M, Häusler I, Antoine R, Coll JL, Resch-Genger U, and Le Guével X

Abstract

Incorporating anisotropic surface charges on atomically precise gold nanoclusters (Au NCs) led to a strong absorption in the near-infrared region and could enable the formation of self-assembled Au NCs exhibiting an intense absorption band at ∼1000 nm. This surface modification showed a striking enhancement of the photoluminescence in the Shortwave Infrared (SWIR) region with a quantum yield as high as 6.1% in water.

Published
2019
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