1. Acid anhydride coated carbon nanodots: activated platforms for engineering clicked (bio)nanoconstructs.
- Author
-
Ortega-Muñoz M, Vargas-Navarro P, Hernandez-Mateo F, Salinas-Castillo A, Capitan-Vallvey LF, Plesselova S, Salto-Gonzalez R, Giron-Gonzalez MD, Lopez-Jaramillo FJ, and Santoyo-Gonzalez F
- Subjects
- Animals, Cell Line, Citric Acid chemistry, Erythrocytes cytology, Erythrocytes drug effects, Erythrocytes metabolism, Hemolysis drug effects, Humans, Mice, Microscopy, Confocal, Nanostructures toxicity, Pyrolysis, Anhydrides chemistry, Carbon chemistry, Nanostructures chemistry
- Abstract
Activated carbon nanodots functionalized with acid anhydride groups (AA-CNDs) are prepared by one-pot water-free green thermolysis of citric acid. As a proof of concept of their capabilities as appealing and versatile platforms for accessing engineering nanoconstructs, the as-prepared AA-CNDs have been reacted to yield clickable CNDs. Their click bioconjugation with relevant recognizable complementary clickable sugars has led to multivalent CND-based glyconanoparticles that are non-toxic and biorecognizable. The accessibility and intrinsic reactivity of AA-CNDs expand the current toolbox of covalent surface grafting methodologies and provide a wide range of potential applications for engineering (bio)nanoconstructs.
- Published
- 2019
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