1. Infants’ first solid foods: impact on gut microbiota development in two intercontinental cohorts
- Author
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Jennifer C. Stearns, Liene Bervoets, Eileen K. Hutton, Jenifer Li, Elizabeth Gunn, Connor A J Rossel, Katherine M. Morrison, Monique Mommers, Julia Simioni, Michael G. Surette, Russell J. de Souza, Niels van Best, Sara Dizzell, John Penders, Chiara-Maria Homann, RS: NUTRIM - R2 - Liver and digestive health, Med Microbiol, Infect Dis & Infect Prev, RS: CAPHRI - R5 - Optimising Patient Care, Epidemiologie, and RS: CAPHRI - R4 - Health Inequities and Societal Participation
- Subjects
Male ,0301 basic medicine ,dietary diversity ,Gut flora ,Cohort Studies ,Eating ,Feces ,Diversity index ,RNA, Ribosomal, 16S ,complementary foods ,TX341-641 ,Infant Nutritional Physiological Phenomena ,gut community ,Phylogeny ,Netherlands ,media_common ,ASSOCIATIONS ,Nutrition and Dietetics ,biology ,Dietary intake ,digestive, oral, and skin physiology ,Biodiversity ,Solid food ,Female ,Infant Food ,BACTERIAL COMMUNITIES ,infant gut microbiome ,media_common.quotation_subject ,030106 microbiology ,Dietary diversity ,Zoology ,Article ,DIET ,03 medical and health sciences ,INTESTINAL MICROBIOTA ,Humans ,Microbiome ,16S rRNA ,introduction to solids ,Bacteria ,infant nutrition ,Nutrition. Foods and food supply ,Infant ,biology.organism_classification ,Gastrointestinal Microbiome ,030104 developmental biology ,microbial diversity ,ESTABLISHMENT ,Species richness ,human activities ,Food Science ,Diversity (politics) - Abstract
The introduction of solid foods is an important dietary event during infancy that causes profound shifts in the gut microbial composition towards a more adult-like state. Infant gut bacterial dynamics, especially in relation to nutritional intake remain understudied. Over 2 weeks surrounding the time of solid food introduction, the day-to-day dynamics in the gut microbiomes of 24 healthy, full-term infants from the Baby, Food &, Mi and LucKi-Gut cohort studies were investigated in relation to their dietary intake. Microbial richness (observed species) and diversity (Shannon index) increased over time and were positively associated with dietary diversity. Microbial community structure (Bray–Curtis dissimilarity) was determined predominantly by individual and age (days). The extent of change in community structure in the introductory period was negatively associated with daily dietary diversity. High daily dietary diversity stabilized the gut microbiome. Bifidobacterial taxa were positively associated, while taxa of the genus Veillonella, that may be the same species, were negatively associated with dietary diversity in both cohorts. This study furthers our understanding of the impact of solid food introduction on gut microbiome development in early life. Dietary diversity seems to have the greatest impact on the gut microbiome as solids are introduced.
- Published
- 2021
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