1. Intradialytic changes of plasma amino acid levels: effect of hemodiafiltration with endogenous reinfusion versus acetate-free biofiltration.
- Author
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Borrelli S, Minutolo R, De Nicola L, Zamboli P, Iodice C, De Paola A, De Simone E, Zito B, Guastaferro P, Nigro F, Apperti V, Iulianiello G, Credendino O, Iacono G, Di Serafino A, D'Apice L, Saviano C, Sarti A, Capuano M, Genualdo R, Auricchio M, Merola M, and Conte G
- Subjects
- Aged, Cross-Sectional Studies, Hemodialysis Solutions administration & dosage, Humans, Middle Aged, Amino Acids blood, Hemodiafiltration, Renal Dialysis
- Abstract
During hemodialysis, amino acids (AA) are lost in the ultrafiltrate with consequent modification of their plasma profile. The aim of this cross-sectional study was to evaluate intradialytic changes of plasma AA levels during a single session of hemodiafiltration with endogenous reinfusion (HFR) versus acetate-free biofiltration (AFB). 48 patients chronically treated with HFR or AFB were matched 1:1 for age, gender, Kt/V and diabetes. Blood samples were collected at the beginning and the end of dialysis. Baseline plasma levels (μmol/l) of total AA (3,176 ± 722), essential AA (889 ± 221), and branched chain AA (459 ± 140) levels in HFR were similar to those in AFB (3,399 ± 621, 938 ± 277, and 463 ± 71, respectively). Plasma intradialytic AA levels did not change in HFR, while in AFB there was a reduction by about 25%. In conclusion, as compared with AFB, HFR has a sparing effect on AA loss due to the lack of adsorption by cartridge and to their complete reinfusion in blood., (Copyright © 2010 S. Karger AG, Basel.)
- Published
- 2010
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