1. Remote Ischemic Preconditioning May Attenuate Renal Ischemia-Reperfusion Injury in a Porcine Model of Supraceliac Aortic Cross-Clamping.
- Author
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Athanasiadis D, Kapelouzou A, Martikos G, Katsimpoulas M, Schizas D, Vasdekis SN, Kostakis A, Liakakos TD, and Lazaris AM
- Subjects
- Acute Kidney Injury blood, Acute Kidney Injury etiology, Acute Kidney Injury physiopathology, Animals, Aorta, Thoracic physiopathology, C-Reactive Protein metabolism, Constriction, Cystatin C blood, Inflammation Mediators blood, Lipocalins blood, Male, Malondialdehyde blood, Models, Animal, Regional Blood Flow, Reperfusion Injury blood, Reperfusion Injury etiology, Reperfusion Injury physiopathology, Swine, Time Factors, Tumor Necrosis Factor-alpha blood, Acute Kidney Injury prevention & control, Aorta, Thoracic surgery, Ischemic Preconditioning methods, Kidney metabolism, Kidney physiopathology, Reperfusion Injury prevention & control
- Abstract
Aim: The effect of remote ischemic preconditioning (RIPC) in decreasing renal ischemia-reperfusion injury (IRI) during a suprarenal aortic cross-clamping was examined in a swine model., Materials and Methods: Four groups of pigs were examined: (a) ischemia-reperfusion (IR) group, renal IRI produced by 30 min of supraceliac aortic cross-clamping; (b) RIPC I group, the same renal IRI following RIPC by brief occlusion of the infrarenal aorta (15 min ischemia and 15 min reperfusion); (c) RIPC II group, the same renal IRI following RIPC by brief occlusion of the infrarenal aorta (3 cycles of 5 min ischemia and 5 min reperfusion); (d) sham group. Renal function was assessed before and after IRI by examining creatinine, neutrophil gelatinase-associated lipocalin (NGAL), TNF-α, malondialdehyde (MDA), cystatin C and C-reactive protein (CRP) from renal vein blood samples at specific time intervals., Results: Both RIPC groups presented significantly less impaired results compared to the IR group when considering MDA, cystatin C, CRP and creatinine. Between the two RIPC groups, RIPC II presented a better response with regard to CRP, NGAL, TNF-α, MDA and cystatin C., Conclusions: Remote IR protocols and mainly repetitive short periods of cycles of IR ameliorate the biochemical kidney effects of IRI in a model of suprarenal aortic aneurysm repair., (© 2015 S. Karger AG, Basel.)
- Published
- 2015
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