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2. Characteristics of Human Intestinal Acid Sialidase

Author

Scharpé S, Den Tandt Wr, and Adriaenssens K

Subjects
chemistry.chemical_classification, Ganglioside, Adolescent, Lability, Albumin, Infant, Neuraminidase, Substrate (chemistry), Hydrogen-Ion Concentration, Sialidase, Biochemistry, N-Acetylneuraminic Acid, Substrate Specificity, Enzyme, chemistry, Child, Preschool, Intestine, Small, Mole, Sialic Acids, Humans, Child, Glycoprotein, Hymecromone
Abstract

With methylumbelliferyl-N-acetyl-neuraminic acid (MU-NANA) as substrate, acid sialidase was determined in intestinal biopsies of children. The enzyme has an acid pH optimum, a Km value of 4 mmol/l and a pronounced thermal lability which can be partially prevented by the addition of albumin. N-acetyl-neuraminic acid (NANA) and derivatives as well as other glycoprotein and oligosaccharide sialidase substrates inhibit sialidase whereas gangliosides have no effect. This could be an indication that intestinal MU-NANA sialidase is different from ganglioside sialidase as has been reported for many other tissues.

Published
1987

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