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1. Contents Vol. 151, 2010

Author

Jesús Jurado-Palomo, Guro Gafvelin, Tiiu Saarne, Wei Guo, Philippe-Jean Bousquet, Hye Yung Yum, David H. Broide, Gergely Tibor Kozma, Laura Gilmartin, Salvatore Metafora, Salvatore De Maria, Torsten Zuberbier, András Szabó, Yang Zhao, Janet M. Oliver, Beáta Szebeni, Zsolt István Komlósi, Ana María Fiandor-Román, F. Al-Maskari, S. Al-Hammadi, Irina Bobolea, Amato de Paulis, Hans Grönlund, Santiago Quirce, Maria Cartenì, Tereassa Archibeque, Massimo Triggiani, Mark Schuyler, Nella Prevete, Dae Jin Song, György Losonczy, Jiong Yang, Éva Pállinger, Lajos Kovács, Ádám Vannay, George N. Konstantinou, Csaba Ádori, Jae Youn Cho, Cristina Y. Pascual, Gianpietro Ravagnan, Ya-dong Gao, R. Bernsen, Raffaele Ragone, Myung Goo Min, Lorena Diehl, Sofía Sánchez-Pastor, Gianni Marone, Christy A. Tarleton, Krisztina Rusai, Clifford Qualls, Francesca Wanda Rossi, Erna Sziksz, Marina Miller, Nikolaos G. Papadopoulos, Bridget S. Wilson, Marianne van Hage, and Vittoria Metafora

Subjects
Immunology, Immunology and Allergy, General Medicine, Biology
Published
2010

2. Reduced Fc∊RI-Mediated Release of Asthma-Promoting Cytokines and Chemokines from Human Basophils during Omalizumab Therapy

Author

Lorena Diehl, Clifford Qualls, Laura Gilmartin, Christy A. Tarleton, Janet M. Oliver, Mark Schuyler, Tereassa Archibeque, and Bridget S. Wilson

Subjects
Adult, Male, Chemokine, Adolescent, medicine.medical_treatment, Immunology, Inflammation, Omalizumab, Basophil, Immunoglobulin E, Antibodies, Monoclonal, Humanized, Histamine Release, chemistry.chemical_compound, medicine, Immunology and Allergy, Humans, Anti-Asthmatic Agents, Cells, Cultured, Asthma, Original Paper, biology, business.industry, Receptors, IgE, Antibodies, Monoclonal, General Medicine, Middle Aged, medicine.disease, respiratory tract diseases, Antibodies, Anti-Idiotypic, Basophils, Cytokine, medicine.anatomical_structure, chemistry, biology.protein, Cytokines, Female, medicine.symptom, business, Histamine, medicine.drug, Follow-Up Studies
Abstract

Background: Treating asthmatics with the humanized IgE-scavenging antibody, omalizumab (rhuMAb-E25, Xolair®), reduces airways inflammation and asthma symptoms. Previously, omalizumab was shown to cause a dramatic and reversible loss of cell surface high-affinity IgE receptors, FcΕRI, from the peripheral blood basophils of asthmatics. The consequences of receptor loss for the FcΕRI-mediated synthesis and release of cytokines implicated in allergic asthma have not been examined. Methods: Fifteen asthmatic volunteers each received omalizumab for 12 weeks. Peripheral blood basophils were isolated before, during, 2 weeks after and 6 months after omalizumab. Basophils were assayed for the basal and anti-IgE-stimulated release of cytokines, chemokines and histamine. Pooled data were analyzed by repeated measures ANOVA and by paired t tests. Results: Anti-IgE-stimulated human basophils synthesize and release Th2 cytokines (IL-4, IL-13) and chemokines (IL-8, RANTES). The anti-IgE-stimulated release of IL-4, IL-13 and IL-8 was reduced during omalizumab treatment and returned to pretreatment levels after omalizumab withdrawal. Omalizumab did not alter basophil histamine levels or basal and anti-IgE-stimulated histamine release. Conclusions: Omalizumab may reduce asthma symptoms in part by suppressing the FcΕRI-mediated production by basophils of Th2 cytokines and selected chemokines. Anti-IgE-stimulated basophil cytokine synthesis appears more sensitive than histamine release to the loss of FcΕRI caused by omalizumab treatment.

Published
2009

3. Subject Index Vol. 151, 2010

Author

Ádám Vannay, David H. Broide, Myung Goo Min, Torsten Zuberbier, Salvatore De Maria, Gergely Tibor Kozma, Guro Gafvelin, Lajos Kovács, Philippe-Jean Bousquet, Laura Gilmartin, Jesús Jurado-Palomo, Beáta Szebeni, Dae Jin Song, György Losonczy, Gianni Marone, Amato de Paulis, Ya-dong Gao, Hans Grönlund, Tiiu Saarne, Christy A. Tarleton, R. Bernsen, George N. Konstantinou, Santiago Quirce, Tereassa Archibeque, Jae Youn Cho, Irina Bobolea, Zsolt István Komlósi, Vittoria Metafora, Massimo Triggiani, Nella Prevete, Gianpietro Ravagnan, Jiong Yang, Éva Pállinger, Krisztina Rusai, Csaba Ádori, Janet M. Oliver, Marina Miller, Cristina Y. Pascual, Ana María Fiandor-Román, Mark Schuyler, Bridget S. Wilson, Francesca Rossi, Lorena Diehl, Sofía Sánchez-Pastor, András Szabó, S. Al-Hammadi, F. Al-Maskari, Yang Zhao, Raffaele Ragone, Wei Guo, Clifford Qualls, Nikolaos G. Papadopoulos, Hye Yung Yum, Marianne van Hage, Salvatore Metafora, Erna Sziksz, and Maria Cartenì

Subjects
Index (economics), Immunology, Statistics, Immunology and Allergy, Subject (documents), General Medicine, Psychology
Published
2010

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