1. Diastolic Dysfunction and Outcome in Acute Ischemic Stroke
- Author
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Seung-Hoon Lee, Jun Bean Park, Dong-Eog Kim, Seung Sik Hwang, Wi Sun Ryu, Byung-Woo Yoon, Yong Jin Kim, and Sang-Bae Ko
- Subjects
Male ,medicine.medical_specialty ,Population ,Diastole ,030204 cardiovascular system & hematology ,Doppler echocardiography ,Ventricular Dysfunction, Left ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Humans ,Medicine ,cardiovascular diseases ,Myocardial infarction ,education ,Stroke ,Aged ,Retrospective Studies ,Aged, 80 and over ,education.field_of_study ,medicine.diagnostic_test ,business.industry ,Cerebral infarction ,Stroke Volume ,Stroke volume ,Middle Aged ,medicine.disease ,Echocardiography, Doppler ,Treatment Outcome ,Neurology ,Heart failure ,Cardiology ,Female ,Neurology (clinical) ,Cardiology and Cardiovascular Medicine ,business ,Blood Flow Velocity ,030217 neurology & neurosurgery - Abstract
Background: Left ventricular diastolic dysfunction (DD) is associated with an increased mortality in general population and patients with myocardial infarct. In the present study, we investigated whether DD is associated with outcomes after ischemic stroke. Methods: Five hundred and three acute ischemic stroke patients with normal left ventricular ejection fraction (≥50%) were retrospectively included. Echocardiography and tissue Doppler imaging were used to evaluate and grade diastolic function. Ordinal logistic and Cox regression analyses were used to examine relations between DD and modified Rankin Scale (mRS) score at 3 months and mortality after stroke, respectively. Results: Mean age was 67.2 ± 11.8 years and 63% were men. Among parameters of diastolic function, early mitral inflow velocity/early diastolic mitral annulus velocity (E/e') was independently related with higher mRS score at 3 months and mortality after ischemic stroke. The highest quartile of E/e' (>14) was independently associated with higher mRS score (adjusted OR 3.86, 95% CI 2.27-6.54) as well as with mortality (hazards ratio [HR] 2.87, 95% CI 1.17-7.04) as compared to the lowest quartile of E/e' (Conclusion: In patients with ischemic stroke, DD is associated with functional outcome at 3 months and mortality. Our data suggest that more attention should be given to DD in patients with ischemic stroke.
- Published
- 2016
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