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1. Contents Vol. 84, 2013

Author

Ann-Lii Cheng, Satz Mengensatzproduktion, M. Himmel, Jacqueline Whang-Peng, Kiyotaka Nishida, Masayuki Okeya, Takeshi Kuno, Tobias Overbeck, Filippo de Braud, Doris Krause, Chi-Long Chen, Rita Hils, Takanobu Tabuchi, Alexander Traut, Takafumi Tabuchi, Noboru Hirashima, Tomoyuki Tsuzuki, Luigi Celio, Pei-Ying Lee, Konstantinos Kontzoglou, Elena De Benedictis, Yusaku Tanaka, Bernhard C. Danner, Edmund I.Tsuen Chen, Misaki Yokoi, Noboru Urata, Druck Reinhardt Druck Basel, Bjoern Chapuy, Ondra du Bois, Lorenz Truemper, Gerald G. Wulf, Michael Stamatakos, Georgia Tasiopoulou, Chi-Ying F. Huang, Paola Mariani, Regina Waldmann-Beushausen, Timo Hupfeld, Julia Heitz, Francesco Agustoni, Francesca Ricchini, Gyo Motohashi, Philipp Harter, Yusuke Hibino, Hideyuki Ubukata, Masaya Esaki, Masaaki Shimada, Bjoern Güldenzoph, Panoraia Paraskeva, Nobuya Inagaki, Friedrich A. Schöndube, Paraskevas Katsaronis, O. Guntinas-Lichius, Florian Heitz, Annette Fisseler-Eckhoff, M. Hartmann, Eriko Kato, Klaus Willenbrock, Yoshihisa Goto, Zhong-Zhe Lin, Jana Barinoff, Hiroaki Iwase, Thiha Aung, Jiro Shimazaki, Nobumitsu Ryuge, Bunichiro Kato, Andreas du Bois, Silvia Damian, and Yuichi Kida

Subjects
Cancer Research, Oncology, General Medicine
Published
2013
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2. In Patients with Colorectal Cancer, Preoperative Serum Interleukin-6 Level and Granulocyte/Lymphocyte Ratio Are Clinically Relevant Biomarkers of Long-Term Cancer Progression

Author

Jiro Shimazaki, Takanobu Tabuchi, Kiyotaka Nishida, Gyo Motohashi, Takafumi Tabuchi, Hideyuki Ubukata, and Yoshihisa Goto

Subjects
Adult, Male, Oncology, Cancer Research, medicine.medical_specialty, Time Factors, genetic structures, Colorectal cancer, Lymphocyte, Granulocyte, Statistics, Nonparametric, Proinflammatory cytokine, Internal medicine, Biomarkers, Tumor, medicine, Humans, In patient, Clinical significance, Lymphocyte Count, Lymphocytes, Interleukin 6, Aged, Neoplasm Staging, Proportional Hazards Models, Aged, 80 and over, biology, Interleukin-6, Tumor Necrosis Factor-alpha, business.industry, Macrophage Colony-Stimulating Factor, Cancer, General Medicine, Middle Aged, Prognosis, medicine.disease, medicine.anatomical_structure, Multivariate Analysis, Disease Progression, biology.protein, Female, Colorectal Neoplasms, business, Granulocytes
Abstract

Objective: To investigate the clinical significance of the serum inflammatory cytokines and the blood granulocytes/lymphocytes (G/L) ratio in patients with colorectal cancer. Methods: Forty-six patients underwent surgery for colorectal cancer. The G/L ratio and serum inflammatory cytokines including interleukin (IL)-1β, IL-6, IL-8, tumour necrosis factor-α (TNF-α), granulocyte colony-stimulating factor and macrophage colony-stimulating factor (M-CSF) were measured before surgery and correlated with the Tumour Node Metastasis classification and overall survival. Results: Serum IL-6 in T3-4, N1-2, M1 cases and cancer stages III-IV sub-groups was significantly higher than in Tis-2, N0, M0 and cancer stages 0-II sub-groups. The G/L ratio, serum M-CSF and TNF-α in T3-4 cases were significantly higher than in Tis-2 cases. Furthermore, the G/L ratio and serum IL-6 showed a significant inverse correlation with the overall survival, while the G/L ratio showed a significant positive correlation with serum IL-6, TNF-α and M-CSF. Multivariate analysis showed that the serum IL-6 level and G/L ratio were independent risk factors for poor prognosis. Conclusions: In this investigation, a pre-operative high level of serum IL-6 and the G/L ratio appeared to be significant predictive factors for cancer progression and poor prognosis. Accordingly, these variables might be clinically relevant biomarkers in patients with colorectal cancer.

Published
2013
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