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9 results on '"Losappio, Laura"'

1. The Severity and Frequency of Systemic Reactions to Hazelnut Are Significantly Higher in Hazelnut Allergic Patients Monosensitized to Cor a 8 than in Patients Polysensitized to Cor a 1, Cor a 8, and Cor a 9

Author

Pastorello, Elide Anna, primary, Scibilia, Joseph, additional, Rossi, Carlo Maria, additional, Toscano, Alessandro, additional, Losappio, Laura Michelina, additional, Nichelatti, Michele, additional, Aversano, Maria Gloria, additional, and Farioli, Laura, additional

Published
2023
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2. Basal Tryptase High Levels Associated with a History of Arterial Hypertension and Hypercholesterolemia Represent Risk Factors for Severe Anaphylaxis in Hymenoptera Venom-Allergic Subjects over 50 Years Old

Author

Pastorello, Elide Anna, primary, Borgonovo, Linda, additional, Preziosi, Donatella, additional, Schroeder, Jan Walter, additional, Pravettoni, Valerio, additional, Aversano, Maria Gloria, additional, Pastori, Stefano, additional, Bilò, Maria Beatrice, additional, Piantanida, Marta, additional, Losappio, Laura Michelina, additional, Nichelatti, Michele, additional, Rossi, Carlo Maria, additional, and Farioli, Laura, additional

Published
2020
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4. Anti-Neutrophil Cytoplasmic Antibodies Positivity and Anti-Leukotrienes in Eosinophilic Granulomatosis with Polyangiitis: A Retrospective Monocentric Study on 134 Italian Patients

Author

Schroeder, J, Folci, M, Losappio, L, Chevallard, M, Sinico, R, Mirone, C, De Luca, F, Nichelatti, M, Pastorello, E, Schroeder, Jan Walter, Folci, Marco, Losappio, Laura Michelina, Chevallard, Michel, Sinico, Renato Alberto, Mirone, Corrado, De Luca, Fabrizio, Nichelatti, Michele, Pastorello, Elide Anna, Schroeder, J, Folci, M, Losappio, L, Chevallard, M, Sinico, R, Mirone, C, De Luca, F, Nichelatti, M, Pastorello, E, Schroeder, Jan Walter, Folci, Marco, Losappio, Laura Michelina, Chevallard, Michel, Sinico, Renato Alberto, Mirone, Corrado, De Luca, Fabrizio, Nichelatti, Michele, and Pastorello, Elide Anna

Abstract

Background: Eosinophilic granulomatosis with polyangiitis (EGPA) is a systemic vasculitis associated with asthma, anti-neutrophil cytoplasmic antibodies (ANCA) positivity, and tissue eosinophilia. Objective: To describe the presenting clinical features, significant biochemical alterations, and also potential pathogenic factors in adult patients diagnosed in our Center over a period of >20 years. Method: A retrospective study of EGPA patients diagnosed from 1994 to 2019 at ASST Grande Ospedale Metropolitano Niguarda Ca' Granda, Milan (Italy), which was performed according to the 1990 American College of Rheumatology criteria and Chapel Hill Consensus Conference definition. A dataset was compiled, registering demographic and clinical features, biochemical analysis at onset, and also the therapies received 3 months prior to EGPA diagnose. Statistical analyses were subsequently conducted dividing patients in 2 groups based on ANCA positivity and comparing them. Results: Two groups were clearly identified by ANCA serology and specific organ involvement in accordance with literature reports; however, our data underline for the first time the association between anti-leukotriene receptor antagonists (LTRAs) and ANCA positivity. The group of previously treated patients presents an OR of 6.42 to be ANCA positive. This finding could be attributed to an imbalanced stimulation of leukotriene receptors, inducing both mast cells activation and an increased neutrophil extracellular traps release from neutrophils. Conclusion: Despite the limitations of this retrospective study, the association between LTRAs and ANCA antibodies elucidates the mechanism by which innate immunity is directly involved in tolerance breakdown and autoantibodies production. Validation of our results with targeted studies could clarify the differences between ANCA-positive and ANCA-negative patients with important consequences on the use of some drug classes in the treatment of EGPA and asthmatic subjects.

Published
2019

5. Anti-Neutrophil Cytoplasmic Antibodies Positivity and Anti-Leukotrienes in Eosinophilic Granulomatosis with Polyangiitis: A Retrospective Monocentric Study on 134 Italian Patients

Author

Schroeder, Jan Walter, primary, Folci, Marco, additional, Losappio, Laura Michelina, additional, Chevallard, Michel, additional, Sinico, Renato Alberto, additional, Mirone, Corrado, additional, De Luca, Fabrizio, additional, Nichelatti, Michele, additional, and Pastorello, Elide Anna, additional

Published
2019
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6. Mite-Induced Asthma and IgE Levels to Shrimp, Mite, Tropomyosin, Arginine Kinase, and Der p 10 Are the Most Relevant Risk Factors for Challenge-Proven Shrimp Allergy

Author

Farioli, Laura, primary, Losappio, Laura Michelina, additional, Giuffrida, Maria Gabriella, additional, Pravettoni, Valerio, additional, Micarelli, Gianluigi, additional, Nichelatti, Michele, additional, Scibilia, Joseph, additional, Mirone, Corrado, additional, Cavallarin, Laura, additional, Lamberti, Cristina, additional, Balossi, Luca Giuseppe, additional, and Pastorello, Elide Anna, additional

Published
2017
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7. Anti-Amoxicillin Immunoglobulin E, Histamine-2 Receptor Antagonist Therapy and Mast Cell Activation Syndrome Are Risk Factors for Amoxicillin Anaphylaxis

Author

Pastorello, Elide Anna, primary, Stafylaraki, Chrysi, additional, Mirone, Corrado, additional, Preziosi, Donatella, additional, Aversano, Maria Gloria, additional, Mascheri, Ambra, additional, Losappio, Laura Michelina, additional, Ortolani, Valeria, additional, Nichelatti, Michele, additional, and Farioli, Laura, additional

Published
2015
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8. Serum Tryptase: A New Biomarker in Patients with Acute Coronary Syndrome?

Author

Pastorello, Elide Anna, primary, Morici, Nuccia, additional, Farioli, Laura, additional, Di Biase, Matteo, additional, Losappio, Laura Michelina, additional, Nichelatti, Michele, additional, Lupica, Loredana, additional, Schroeder, Jan Walter, additional, Stafylaraki, Chrysi, additional, and Klugmann, Silvio, additional

Published
2014
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9. Rice Allergy Demonstrated by Double-Blind Placebo-Controlled Food Challenge in Peach-Allergic Patients Is Related to Lipid Transfer Protein Reactivity

Author

Pastorello, Elide Anna, primary, Scibilia, Joseph, additional, Farioli, Laura, additional, Primavesi, Laura, additional, Giuffrida, Maria Gabriella, additional, Mascheri, Ambra, additional, Piantanida, Marta, additional, Mirone, Corrado, additional, Stafylaraki, Chrysi, additional, Violetta, Marta Riva, additional, Nichelatti, Michele, additional, Preziosi, Donatella, additional, Losappio, Laura, additional, and Pravettoni, Valerio, additional

Published
2013
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