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1. Contents Vol. 104, 2013

Author

Martin Stocker, Andrea Clarici, Matteo Fontana, Mete Akisu, Stefano Bembich, Satz Mengensatzproduktion, Martin Keszler, Mehmet Nevzat Cizmeci, Katharine A.G. Squires, Stefano Massaccesi, Olaf Dammann, Camilia R. Martin, Pracha Nuntnarumit, Peter A. Dargaville, Mehmet Kenan Kanburoglu, Anne Greenough, Natthachai Muangyod, Roger F. Soll, Anniina Palojärvi, Ahmet Zulfikar Akelma, Chris E. Williams, Sergio Demarini, Thomas M. Berger, Sture Andersson, Hilal Andan, Anant Khositseth, Jari Petäjä, Kayihan Akin, Deena-Shefali Patel, Richard A. Ehrenkranz, Julie Bartholomew, Mehmet Yalaz, Ertürk Levent, Gerrard F. Rafferty, Druck Reinhardt Druck Basel, Silke Lee, Nilgün Kültürsay, Ursula Turpeinen, Thibault Senterre, Cecilia Janér, Riccardo Davanzo, Pierpaolo Brovedani, Simon Hannam, Mustafa Mansur Tatli, Olie Chowdhury, Alan Leviton, Minghua L. Chen, Janet L. Peacock, Elizabeth N. Allred, Antonio G De Paoli, Ozge Altun Koroglu, and Onur Erbukucu

Subjects
Pediatrics, medicine.medical_specialty, Traditional medicine, business.industry, Pediatrics, Perinatology and Child Health, Medicine, business, Developmental Biology
Published
2013
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2. Contents Vol. 98, 2010

Author

J.F. Felix, Anna Koskinen, Bryan S. Richardson, Kevin P. Lally, N. Laforgia, C.F. Poets, James N. MacLachlan, M.J. Butel, Luciana Porto, Mete Akisu, Pekka Kääpä, Kathleen Ayers, M. Gorett Silva, Bilin Cakmak, N. Kalach, Guillaume Emeriaud, Payam Vali, Doris Fischer, Cherrie D. Welch, Gunnel Hellgren, Xiaoping Luo, K. Allegaert, Gulin Erdemir, W.C.J. Hop, T. Schaible, Thierry Debillon, Charles Turner, Sarah E. Fleming, Thomas Pranikoff, Eva Engström, Hüseyin Onay, Gila Benchetrit, Pascale Calabrese, I. Reiss, Ana Remesal, Hanna Soukka, Keirnan L. Willett, Lex W. Doyle, L. van den Hout, Sanjeev Aggarwal, Brad Matushewski, Nasser Chegini, F. Campeotto, Hildegard Stoll, Dolores Ludeña, Girija Natarajan, A. van Heijst, D. Tibboel, Bo Jacobsson, Jeremy D. McCallum, Henry L. Halliday, Patricia M. Schnulle, D. Bassler, N. Kapel, Caroline N. Nguyen, Asta Laiho, I. Capolupo, Nilgün Kültürsay, Elsa Kermorvant-Duchemin, Qing Yang, Laura San Feliciano, Sreedhar Reddy Anne, Alexandre Lapillonne, David M. Hougaard, Joyce M. Koenig, Heikki Lukkarinen, Christof Geisen, Sergio Eleni dit Trolli, Poul Thorsen, Pamela A. Lally, Pierre Baconnier, M. Baldassarre, Jae H. Kim, Richard A. Ehrenkranz, Chatarina Löfqvist, Mehmet Yalaz, André Eberhard, Rolf L. Schloesser, C. Maas, C. Dupont, María Isidoro-García, A. Greenough, L. Amati, Ann Hellström, Norman B. Smith, Ferda Ozkinay, Ozge Altun Koroglu, and V. Viallon

Subjects
Pediatrics, medicine.medical_specialty, Traditional medicine, business.industry, Pediatrics, Perinatology and Child Health, medicine, business, Developmental Biology
Published
2010
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3. Mannose-Binding Lectin Gene Polymorphism and Early Neonatal Outcome in Preterm Infants

Author

Mete Akisu, Ozge Altun Koroglu, Hüseyin Onay, Gulin Erdemir, Nilgün Kültürsay, Bilin Cakmak, Ferda Ozkinay, Mehmet Yalaz, and Ege Üniversitesi

Subjects
Male, Genotype, Turkey, animal diseases, Patent ductus arteriosus, Gestational Age, chemical and pharmacologic phenomena, Inflammation, Infant, Premature, Diseases, Biology, Polymorphism, Single Nucleotide, Severity of Illness Index, Sepsis, medicine, Humans, Genetic Predisposition to Disease, Polymorphism, Gene, Mannan-binding lectin, Preterm newborn, Mannose-binding lectin, Fetal Growth Retardation, Innate immune system, ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS, Infant, Newborn, Lectin, biochemical phenomena, metabolism, and nutrition, bacterial infections and mycoses, medicine.disease, Acquired immune system, ComputingMilieux_MANAGEMENTOFCOMPUTINGANDINFORMATIONSYSTEMS, ComputingMethodologies_PATTERNRECOGNITION, Pediatrics, Perinatology and Child Health, Immunology, biology.protein, bacteria, Female, Gene polymorphism, InformationSystems_MISCELLANEOUS, medicine.symptom, Infant, Premature, Developmental Biology
Abstract

PubMed ID: 20453525, Background: Mannose-binding lectin (MBL) as a component of innate immunity plays an important role in preterm infants in whom adaptive immunity is not sufficiently developed. Polymorphisms in immunoregulatory genes influence the response to infection and subsequent inflammation. Infection and inflammation have been implicated in the mechanisms responsible for many of the diseases in the preterm newborns. Objectives: The aim of the study was to investigate the relationship between MBL gene polymorphism and early neonatal outcome in preterm infants. Methods: Codon 54 and 57 polymorphisms in MBL2 gene were genotyped in 99 preterm infants admitted to the Neonatal Intensive Care Unit at Ege University Children's Hospital. Results: Overall frequencies of sepsis and early-onset sepsis were higher in the group of infants with MBL polymorphism when compared to infants with wild-type MBL genotype (p = 0.008, 0.009, respectively). Maximum Tollner sepsis score in the first 3 days of life was higher for the infants with variant MBL genotype (p = 0.0278). More infants in the variant MBL group had significant patent ductus arteriosus when compared to infants with wild-type MBL (27.8 vs. 9.5% respectively, p = 0.037). Conclusion: MBL gene polymorphism was associated with increased frequency of clinical sepsis particularly with early neonatal sepsis and also with higher Tollner sepsis scores and increased frequency of patent ductus arteriosus in infants. Overall mortality and incidence of culture proven sepsis, respiratory distress syndrome, bronchopulmonary dysplasia, intraventricular hemorrhage, periventricular leukomalacia and necrotizing enterocolitis were not found to be related to MBL genotype. © 2010 S. Karger AG, Basel.

Published
2010
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4. Cooling for Newborns with Hypoxic Ischemic Encephalopathy

Author

Anniina Palojärvi, Matteo Fontana, Gerrard F. Rafferty, Hilal Andan, Roger F. Soll, Sture Andersson, Antonio G De Paoli, Ozge Altun Koroglu, Kayihan Akin, Nilgün Kültürsay, Ursula Turpeinen, Onur Erbukucu, Martin Keszler, Mehmet Nevzat Cizmeci, Jari Petäjä, Andrea Clarici, Ertürk Levent, Thomas M. Berger, Deena-Shefali Patel, Stefano Bembich, Camilia R. Martin, Janet L. Peacock, Thibault Senterre, Olaf Dammann, Anne Greenough, Mete Akisu, Ahmet Zulfikar Akelma, Olie Chowdhury, Elizabeth N. Allred, Julie Bartholomew, Richard A. Ehrenkranz, Katharine A.G. Squires, Chris E. Williams, Mehmet Yalaz, Peter A. Dargaville, Mehmet Kenan Kanburoglu, Anant Khositseth, Satz Mengensatzproduktion, Silke Lee, Pracha Nuntnarumit, Pierpaolo Brovedani, Cecilia Janér, Mustafa Mansur Tatli, Sergio Demarini, Druck Reinhardt Druck Basel, Alan Leviton, Martin Stocker, Minghua L. Chen, Riccardo Davanzo, Stefano Massaccesi, Simon Hannam, and Natthachai Muangyod

Subjects
business.industry, Anesthesia, Pediatrics, Perinatology and Child Health, Medicine, business, Hypoxic Ischemic Encephalopathy, Developmental Biology
Published
2013
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5. Submitted Posters (pp 557–606)

Author

V. Boschi, Daniel König, P. D’Orsi, W.H.M. Saris, A. Ramel, Peter Deibert, A. Žák, Nilgün Kültürsay, M. Gröschl, E. Trapanese, Meral Baka, J. Rambousková, B. Staňková, I. Thorsdottir, E. Tvrzická, G. Nasti, F. Basile, M. Rauh, Afig Huseyinov, C. Falconi, J. Fanta, Ravinder Nath, D. Kubisová, I. Knerr, Jyotika Attri, Andreas Berg, Manfred W. Baumstark, P. Dlouhý, A. Oloo, Aloys Berg, O. Bellini, Achim Bub, Z. Straka, D. Bílková, A. Papa, M. Vecka, Gerhard Rechkemmer, Mete Akisu, W.D. van Marken Lichtenbelt, M. Siervo, G.A. Ettyang, Dominik Grathwohl, W. Rascher, H.K. Parwana, J. Pachl, Ingomar-Werner Franz, Karlis Briviba, Bernhard Watzl, Veena Dhawan, Safrun Mahmood, Promila Pandhi, N. Margiotta, and M. Anděl

Subjects
Gerontology, Nutrition and Dietetics, business.industry, Medicine (miscellaneous), Library science, Medicine, business
Published
2003
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6. Submitted Oral Communications

Author

Meral Baka, I. Knerr, Andreas Berg, Mete Akisu, Jyotika Attri, C. Falconi, B. Staňková, M. Rauh, M. Siervo, W. Rascher, H.K. Parwana, G.A. Ettyang, O. Bellini, Achim Bub, A. Oloo, Z. Straka, V. Boschi, A. Papa, J. Pachl, I. Thorsdottir, Veena Dhawan, P. D’Orsi, G. Nasti, P. Dlouhý, Karlis Briviba, W.H.M. Saris, E. Tvrzická, Manfred W. Baumstark, F. Basile, D. Bílková, Bernhard Watzl, W.D. van Marken Lichtenbelt, J. Fanta, Daniel König, Ingomar-Werner Franz, Gerhard Rechkemmer, Peter Deibert, Safrun Mahmood, Promila Pandhi, D. Kubisová, N. Margiotta, M. Anděl, Aloys Berg, A. Ramel, Nilgün Kültürsay, M. Gröschl, E. Trapanese, Ravinder Nath, M. Vecka, A. Žák, J. Rambousková, Dominik Grathwohl, and Afig Huseyinov

Subjects
Nutrition and Dietetics, Medicine (miscellaneous)
Published
2003
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7. Plenary Sessions and Simposia – Research

Author

D. Bílková, W.H.M. Saris, Aloys Berg, W.D. van Marken Lichtenbelt, Bernhard Watzl, Andreas Berg, Mete Akisu, Nilgün Kültürsay, M. Gröschl, A. Ramel, I. Knerr, E. Trapanese, M. Rauh, V. Boschi, W. Rascher, H.K. Parwana, Peter Deibert, A. Žák, M. Anděl, P. D’Orsi, P. Dlouhý, E. Tvrzická, J. Rambousková, F. Basile, O. Bellini, Dominik Grathwohl, Afig Huseyinov, J. Fanta, I. Thorsdottir, Achim Bub, B. Staňková, G. Nasti, N. Margiotta, Manfred W. Baumstark, D. Kubisová, Safrun Mahmood, Ravinder Nath, Promila Pandhi, J. Pachl, M. Siervo, G.A. Ettyang, Daniel König, M. Vecka, A. Oloo, Ingomar-Werner Franz, Meral Baka, C. Falconi, Z. Straka, A. Papa, Karlis Briviba, Veena Dhawan, Gerhard Rechkemmer, and Jyotika Attri

Subjects
Gerontology, Nutrition and Dietetics, business.industry, Medicine (miscellaneous), Medicine, business
Published
2003
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8. Plenary Sessions and Simposia – Health

Author

E. Tvrzická, F. Basile, J. Fanta, Mete Akisu, O. Bellini, Achim Bub, Jyotika Attri, W. Rascher, A. Ramel, H.K. Parwana, Daniel König, V. Boschi, B. Staňková, Andreas Berg, Veena Dhawan, Z. Straka, P. D’Orsi, A. Papa, I. Knerr, Meral Baka, W.H.M. Saris, Bernhard Watzl, Karlis Briviba, D. Bílková, I. Thorsdottir, D. Kubisová, W.D. van Marken Lichtenbelt, G. Nasti, M. Rauh, M. Siervo, Gerhard Rechkemmer, A. Oloo, G.A. Ettyang, Ingomar-Werner Franz, Peter Deibert, P. Dlouhý, J. Pachl, Manfred W. Baumstark, C. Falconi, N. Margiotta, M. Anděl, Safrun Mahmood, Promila Pandhi, Nilgün Kültürsay, M. Gröschl, E. Trapanese, A. Žák, J. Rambousková, Dominik Grathwohl, Afig Huseyinov, Aloys Berg, Ravinder Nath, and M. Vecka

Subjects
Gerontology, Medical education, Nutrition and Dietetics, business.industry, Medicine (miscellaneous), Medicine, business
Published
2003
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9. Submitted Posters (pp 465–556)

Author

V. Boschi, P. D’Orsi, Ravinder Nath, M. Vecka, M. Rauh, Nilgün Kültürsay, M. Gröschl, E. Trapanese, A. Oloo, Andreas Berg, O. Bellini, Achim Bub, Gerhard Rechkemmer, P. Dlouhý, Jyotika Attri, D. Bílková, E. Tvrzická, W.D. van Marken Lichtenbelt, F. Basile, M. Anděl, J. Fanta, N. Margiotta, Safrun Mahmood, A. Ramel, Promila Pandhi, Daniel König, Meral Baka, Mete Akisu, I. Knerr, C. Falconi, W. Rascher, H.K. Parwana, Bernhard Watzl, Manfred W. Baumstark, D. Kubisová, Aloys Berg, M. Siervo, G.A. Ettyang, Karlis Briviba, Ingomar-Werner Franz, Peter Deibert, I. Thorsdottir, G. Nasti, J. Pachl, W.H.M. Saris, Z. Straka, A. Papa, Veena Dhawan, A. Žák, B. Staňková, J. Rambousková, Dominik Grathwohl, and Afig Huseyinov

Subjects
Gerontology, Nutrition and Dietetics, business.industry, Medicine (miscellaneous), Library science, Medicine, business
Published
2003
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10. Protective Effect of Dietary Supplementation with L-Arginine and L-Carnitine on Hypoxia/Reoxygenation-Induced Necrotizing Enterocolitis in Young Mice

Author

Dilek Özmen, Mete Akisu, Sertac Arslanoglu, Meral Baka, Mehmet Yalaz, Nilgün Kültürsay, Oya Bayindir, and Sara Habif

Subjects
Enterocolitis, medicine.medical_specialty, Pathology, Necrosis, Arginine, Ratón, Biology, medicine.disease, digestive system diseases, Nitric oxide, Lipid peroxidation, chemistry.chemical_compound, Endocrinology, chemistry, Internal medicine, Pediatrics, Perinatology and Child Health, Necrotizing enterocolitis, medicine, Carnitine, medicine.symptom, Developmental Biology, medicine.drug
Abstract

Oxygen-derived free radicals are important components of gastrointestinal injury in necrotizing enterocolitis (NEC). In the present investigation, we examined the protective actions of L-arginine, a nitric oxide synthase substrate, and L-carnitine against hypoxia-reoxygenation (H/R) induced NEC in young mice. Young mice were divided into four groups: group 1 mice were subjected to H/R only; group 2 H/R mice were supplemented with L-arginine in the drinking water (2 g/l) for 7 days; group 3 H/R mice were given L-carnitine solution in water (50 mg/kg p.o.) for 7 days, and group 4 mice served as controls.Hypoxia was induced by placing the mice in a 100% CO2 chamber for 5 min. After hypoxia, the mice were reoxygenated for 10 min with 100% oxygen. We examined the intestinal lesions by light microscopy and measured the intestinal generation of thiobarbituric acid reactive substances (TBARS) and the activities of superoxide dismutase and catalase in the H/R-induced model of NEC. In both L-arginine and L-carnitine groups, the NEC-induced intestinal tissue damage was greatly attenuated, with necrosis limited partially to the mucosa. The tissue TBARS level was significantly higher in group 1 than in any of the other groups (p < 0.001). However, those treated with L-arginine and L-carnitine had TBARS levels similar to those in the control animals. An increased tissue concentration of nitrate, a stable metabolite of nitric oxide, was found in the L-arginine-supplemented group as compared with the control group (p < 0.05). Both superoxide dismutase and catalase activities in the intestine were similar in H/R groups when compared with the intestine of control animals. The present study suggests that oxygen-derived free radicals are involved in the pathogenesis of H/R-induced NEC. This study also shows that dietary supplementation with L-arginine and L-carnitine ameliorates the histological evidence of H/R-induced intestinal injury and significantly decreases lipid peroxidation in H/R-induced bowel injury. Based on these findings, the beneficial effects of L-arginine and L-carnitine in this model may be mediated via mechanisms preventing free radical damage.

Published
2002
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11. Myocardial and Hepatic Free Carnitine Concentrations in Pups of Diabetic Female Rats

Author

Işıl Çoker, Mete Akisu, Afig Huseyinov, and Nilgün Kültürsay

Subjects
medicine.medical_specialty, Heart disease, Cardiomyopathy, Medicine (miscellaneous), Diabetes Mellitus, Experimental, Pregnancy, Carnitine, Diabetes mellitus, Internal medicine, medicine, Animals, Rats, Wistar, chemistry.chemical_classification, Nutrition and Dietetics, business.industry, Myocardium, Hypertrophic cardiomyopathy, Fatty acid, Heart, medicine.disease, Streptozotocin, Rats, Endocrinology, Animals, Newborn, Liver, chemistry, Dietary Supplements, Female, Cardiomyopathies, business, Injections, Intraperitoneal, medicine.drug
Abstract

Background/Aims: Adequate carnitine levels are required for normal fatty acid and energy metabolism in heart muscle. It is well known that streptozotocin-induced diabetic rats develop myocardial carnitine deficiency and that carnitine therapy may be beneficial to the diabetic heart. Infants of diabetic mothers (IDM) are known to be at risk for developing a hypertrophic type of cardiomyopathy. In the present investigation, we examined the free carnitine concentration from cardiac and hepatic tissue in pups of streptozotocin-induced diabetic female rats. We also assessed the effect of maternal L-carnitine supplementation on the free carnitine concentration in pups of diabetic rats. Method: Three groups, each consisting of 4 Wistar albino female rats, were studied, Group 1 (untreated diabetic; n = 4) and group 2 (L-carnitine-treated diabetic; n = 4) rats were given streptozotocin (60 mg/kg) by intraperitoneal injection; group 3 were controls. During pregnancy, L-carnitine was given at a dose of 150 mg/kg by intraperitoneal injection once a day for 14 days. Cesarean section was carried out, and 113 newborn rats (group 1 n = 36; group 2 n = 38; group 3 n = 39) were obtained from all the pregnant rats. Results: The free carnitine concentration in myocardial tissue was significantly decreased in the female diabetic rats (p < 0.001). However, the free carnitine concentration from hepatic tissue in diabetic female rats was similar to that in controls. In pups of group 1 diabetic rats, a significantly decreased free carnitine concentration was found in both myocardial and hepatic tissue compared to group 2 and controls. The free carnitine content from myocardial and hepatic tissue was significantly elevated in the maternal L-carnitine-supplemented group when compared to group 1 and control pups (p < 0.001 and p < 0.05, respectively). Conclusions: The present study has demonstrated that the free carnitine concentration from myocardial and hepatic tissue is significantly reduced in pups of streptozotocin-induced diabetic female rats. This study has also shown that administration of maternal L-carnitine improves the carnitine level in pups of diabetic rats. A decreased myocardial carnitine concentration may be partly responsible for the development of cardiomyopathy in IDM.

Published
2002
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12. Effect of Dietary n–3 Fatty Acids on Hypoxia-Induced Necrotizing Enterocolitis in Young Mice

Author

Mete Akisu, Işıl Çoker, Meral Baka, Nilgün Kültürsay, and Afig Huseyinov

Subjects
Enterocolitis, medicine.medical_specialty, Platelet-activating factor, Ratón, Leukotriene B4, Biology, Hypoxia (medical), Fish oil, medicine.disease, chemistry.chemical_compound, Endocrinology, chemistry, Internal medicine, Pediatrics, Perinatology and Child Health, Immunology, Necrotizing enterocolitis, medicine, Tumor necrosis factor alpha, medicine.symptom, Developmental Biology
Abstract

Necrotizing entercolitis (NEC) is an important neonatal disease with a high mortality rate. Inflammatory mediators, such as mainly platelet-activating factor (PAF), leukotrienes (LT) and tumor necrosis factor play an important role in the genesis of NEC. Diets in Ω–3 (n–3) fatty acids appear to have an antiinflammatory effect, which is thought to be due to decreased active prostaglandins and leukotrienes production after incorporation of these fatty acids into cell membrane phospholipids. We investigated the protective effect of fish oil (source of n–3 fatty acids) on hypoxia-induced model of NEC. Young mice were divided into three groups; group 1 mice were fed standard chow (n–3 fatty acids-free), group 2 was fed a chow supplemented by 10% fish oil for 4 weeks. Group 3 mice served as control. We examined the intestinal lesions by light microscopy and measured intestinal tissue PAF and LB4 levels in hypoxia-induced model of NEC. Significantly increased intestinal PAF and LTB4 levels were found in group 1 mice when compared to group 2 and group 3 mice. The histopathology of the intestinal lesions in group 1 animals was characteristic of ischemic injury. In the n–3 fatty acids-supplemented animals these lesions were milder. The present study shows that endogenously released PAF and LTB4 play an important role in mediating hypoxia-induced intestinal necrosis. The present study also suggests that dietary supplementation with n–3 fatty acids suppress intestinal PAF and LTB4 generation in hypoxia-induced bowel necrosis. The intestinal protective effect of n–3 fatty acids in an experimental model of NEC may open new insight into the treatment and preventation of NEC in neonates.

Published
1998
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13. Platelet-Activating Factor Is an Important Mediator in Hypoxic Ischemic Brain Injury in the Newborn Rat

Author

Işıl Çoker, Mete Akisu, Afig Huseyinov, and Nilgün Kültürsay

Subjects
medicine.medical_specialty, Platelet-activating factor, biology, business.industry, Ginkgo biloba, medicine.drug_class, Encephalopathy, Ischemia, Endogeny, Calcium channel blocker, medicine.disease, biology.organism_classification, chemistry.chemical_compound, Endocrinology, chemistry, Internal medicine, Pediatrics, Perinatology and Child Health, Medicine, Ginkgoales, business, Flunarizine, Developmental Biology, medicine.drug
Abstract

Hypoxic-ischemic encephalopathy is still a very important cause of neonatal mortality and morbidity. Recently, platelet-activating factor (PAF) has been accused of being responsible for the neuronal damage in hypoxic-ischemic brain. We investigated tissue PAF concentrations in hypoxic-ischemic brain injury in immature rats. Endogenous PAF concentration in brain tissue showed a marked increase in hypoxic-ischemic pups (85.6 ± 15.5 pg/mg protein) when compared to that of control (9.05 ± 3.1 pg/mg protein). In addition, we examined the effects of flunarizine, a selective calcium channel blocker, and Ginkgo biloba extract (EGb 761) on endogenous PAF concentration in hypoxic-ischemic brain injury. Endogenous PAF concentrations in both flunarizine-pretreated (16.6 ± 4.8 pg/mg protein) and EGb 761-pretreated (33.5 ± 8.9 pg/mg protein) pups were significantly lower than the untreated group. These results indicate that PAF is an important mediator in immature rat model of cerebral hypoxic-ischemic injury. The suppressor effect of flunarizine and EGb 761 on PAF production may open new insight into the treatment of hypoxic-ischemic brain injury.

Published
1998
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14. Platelet-Activating Factor Levels in Term and Preterm Human Milk

Author

Işıl Çoker, Mete Akisu, Nese Özkayin, Nilgün Kültürsay, and Afig Huseyinov

Subjects
Male, medicine.medical_specialty, Gestational Age, Breast milk, Pathogenesis, chemistry.chemical_compound, Internal medicine, medicine, Humans, Platelet Activating Factor, Enterocolitis, Pseudomembranous, Enterocolitis, Milk, Human, Platelet-activating factor, business.industry, Colostrum, Infant, Newborn, Gestational age, medicine.disease, Endocrinology, chemistry, Pediatrics, Perinatology and Child Health, Necrotizing enterocolitis, Gestation, Female, medicine.symptom, business, Infant, Premature, Developmental Biology
Abstract

It is well known that necrotizing enterocolitis (NEC) is less frequent in newborns being fed human breast milk. Since recent studies indicated that platelet-activating factor (PAF) plays an important role in pathogenesis of NEC, this study was conducted to investigate the PAF levels in human milk. Colostrum and mature human milk (samples obtained in the third week) of three groups of mothers were investigated. The first group had given birth within less than 32 weeks, the second between 33–37 weeks and the third group after 38 weeks of gestation. The PAF levels in colostrum of all three groups were similar (0.95 ± 0.57, 1.05 ± 0.52 and 1.19 ± 0.64 ng/ml, respectively). Mature human milk in groups I and II had similar PAF levels (1.16 ± 0.54 and 1.21 ± 0.60 ng/ml, respectively), however, mature human milk in group III had a significantly higher PAF concentration (2.04 ± 0.59 ng/ml) than both groups’ levels. However, this phenomenon by itself does not explain the protective effect of human milk against NEC.

Published
1998
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15. Subject Index Vol. 98, 2010

Author

Keirnan L. Willett, Mete Akisu, Caroline N. Nguyen, Nilgün Kültürsay, Jeremy D. McCallum, Qing Yang, Laura San Feliciano, Hüseyin Onay, Sreedhar Reddy Anne, C.F. Poets, Hanna Soukka, Joyce M. Koenig, Heikki Lukkarinen, Bilin Cakmak, André Eberhard, Payam Vali, Girija Natarajan, Hildegard Stoll, Sergio Eleni dit Trolli, K. Allegaert, Gulin Erdemir, T. Schaible, Doris Fischer, Cherrie D. Welch, I. Reiss, Rolf L. Schloesser, C. Maas, L. van den Hout, Pamela A. Lally, C. Dupont, Thomas Pranikoff, Guillaume Emeriaud, D. Tibboel, Ozge Altun Koroglu, A. van Heijst, Alexandre Lapillonne, A. Greenough, Pekka Kääpä, Kathleen Ayers, Lex W. Doyle, J.F. Felix, V. Viallon, Pierre Baconnier, Charles Turner, Jae H. Kim, Ferda Ozkinay, Richard A. Ehrenkranz, Poul Thorsen, Chatarina Löfqvist, Mehmet Yalaz, María Isidoro-García, Sanjeev Aggarwal, Ana Remesal, M.J. Butel, Pascale Calabrese, Elsa Kermorvant-Duchemin, Anna Koskinen, Thierry Debillon, L. Amati, Kevin P. Lally, N. Kapel, Ann Hellström, N. Laforgia, Patricia M. Schnulle, M. Gorett Silva, D. Bassler, F. Campeotto, Christof Geisen, Xiaoping Luo, Asta Laiho, I. Capolupo, M. Baldassarre, Bo Jacobsson, Eva Engström, Gunnel Hellgren, Nasser Chegini, Henry L. Halliday, N. Kalach, Brad Matushewski, Bryan S. Richardson, W.C.J. Hop, Norman Smith, Gila Benchetrit, James N. MacLachlan, Dolores Ludeña, David M. Hougaard, Sarah E. Fleming, and Luciana Porto

Subjects
medicine.medical_specialty, Pediatrics, Index (economics), business.industry, Pediatrics, Perinatology and Child Health, Physical therapy, medicine, Subject (documents), business, Developmental Biology
Published
2010
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16. Special Sessions/Debates

Author

Gerhard Rechkemmer, Peter Deibert, Veena Dhawan, V. Boschi, Andreas Berg, Bernhard Watzl, P. D’Orsi, M. Siervo, A. Oloo, G.A. Ettyang, I. Thorsdottir, Mete Akisu, G. Nasti, N. Margiotta, B. Staňková, Manfred W. Baumstark, Meral Baka, Jyotika Attri, W. Rascher, H.K. Parwana, Karlis Briviba, M. Anděl, E. Tvrzická, J. Pachl, C. Falconi, F. Basile, O. Bellini, Achim Bub, J. Fanta, W.H.M. Saris, Safrun Mahmood, D. Kubisová, Promila Pandhi, Ingomar-Werner Franz, A. Žák, Daniel König, Z. Straka, A. Papa, J. Rambousková, Dominik Grathwohl, Afig Huseyinov, Ravinder Nath, M. Vecka, Nilgün Kültürsay, M. Gröschl, E. Trapanese, A. Ramel, Aloys Berg, M. Rauh, I. Knerr, P. Dlouhý, D. Bílková, and W.D. van Marken Lichtenbelt

Subjects
Gerontology, Medical education, Nutrition and Dietetics, business.industry, Medicine (miscellaneous), Medicine, business
Published
2003
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17. Subject Index Vol. 47, 2003

Author

V. Boschi, P. D’Orsi, A. Žák, Mete Akisu, I. Knerr, J. Rambousková, Dominik Grathwohl, Afig Huseyinov, Ingomar-Werner Franz, E. Tvrzická, W. Rascher, H.K. Parwana, F. Basile, J. Fanta, D. Bílková, Jyotika Attri, W.H.M. Saris, Andreas Berg, A. Oloo, A. Ramel, Peter Deibert, W.D. van Marken Lichtenbelt, M. Rauh, Veena Dhawan, Bernhard Watzl, Z. Straka, B. Staňková, Gerhard Rechkemmer, A. Papa, Aloys Berg, P. Dlouhý, O. Bellini, Achim Bub, J. Pachl, Manfred W. Baumstark, Karlis Briviba, M. Siervo, G.A. Ettyang, I. Thorsdottir, G. Nasti, Daniel König, Nilgün Kültürsay, M. Gröschl, E. Trapanese, D. Kubisová, Ravinder Nath, M. Vecka, M. Anděl, N. Margiotta, Safrun Mahmood, Promila Pandhi, Meral Baka, and C. Falconi

Subjects
Gerontology, Nutrition and Dietetics, Index (economics), business.industry, Medicine (miscellaneous), Medicine, Subject (documents), business
Published
2003
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18. Contents Vol. 47, 2003

Author

A. Oloo, Daniel König, M. Anděl, D. Bílková, Mete Akisu, V. Boschi, I. Thorsdottir, W. Rascher, P. D’Orsi, G. Nasti, H.K. Parwana, N. Margiotta, W.D. van Marken Lichtenbelt, Meral Baka, Andreas Berg, D. Kubisová, A. Ramel, Gerhard Rechkemmer, M. Rauh, Safrun Mahmood, Veena Dhawan, Promila Pandhi, Bernhard Watzl, C. Falconi, Aloys Berg, W.H.M. Saris, E. Tvrzická, F. Basile, Ingomar-Werner Franz, Manfred W. Baumstark, P. Dlouhý, J. Fanta, Karlis Briviba, A. Žák, M. Siervo, G.A. Ettyang, I. Knerr, J. Rambousková, Z. Straka, A. Papa, J. Pachl, Dominik Grathwohl, Afig Huseyinov, Ravinder Nath, M. Vecka, Peter Deibert, B. Staňková, Nilgün Kültürsay, M. Gröschl, E. Trapanese, O. Bellini, Achim Bub, and Jyotika Attri

Subjects
Gerontology, Nutrition and Dietetics, Anthropology, Philosophy, Medicine (miscellaneous)
Published
2003
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19. Subject Index Vol. 81, 2002

Author

Erik Harms, Mete Akisu, Richard Plavka, Jörg Wüllenweber, Nilgün Kültürsay, Gerd Jorch, Hana Hansikova, Gert Lubec, Frank Louwen, Monica Miozzo, Olga Labudova, Oya Bayindir, Wolfgang Sperl, Sertac Arslanoglu, Dilek Özmen, Lothar Schrod, Sara Habif, L. Kirchner, Bruno Kastler, Barbara Lubec, Mehmet Yalaz, Harald Hoeger, O. de Bethmann, Jiří Zeman, Meral Baka, Henk S.P. Garritsen, Thomas Brune, Laszlo Wenchich, M. Monset-Couchard, Anette Schlake, Ralf Witteler, Giuseppe Simoni, Josef Houštěk, and Julia Walter

Subjects
Index (economics), Anthropology, Pediatrics, Perinatology and Child Health, Physiology, Subject (documents), Psychology, Developmental Biology
Published
2002
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20. Contents Vol. 81, 2002

Author

Lothar Schrod, Sara Habif, L. Kirchner, Mehmet Yalaz, Erik Harms, Sertac Arslanoglu, Ralf Witteler, Monica Miozzo, Nilgün Kültürsay, Dilek Özmen, Bruno Kastler, Giuseppe Simoni, M. Monset-Couchard, Hana Hansikova, Henk S.P. Garritsen, Gert Lubec, Gerd Jorch, O. de Bethmann, Jiří Zeman, Julia Walter, Frank Louwen, Richard Plavka, Josef Houštěk, Olga Labudova, Thomas Brune, Wolfgang Sperl, Jörg Wüllenweber, Barbara Lubec, Oya Bayindir, Anette Schlake, Harald Hoeger, Meral Baka, Laszlo Wenchich, and Mete Akisu

Subjects
Pediatrics, Perinatology and Child Health, Developmental Biology
Published
2002
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21. Acknowledgement to the 2003 Reviewers

Author

Ravinder Nath, D. Bílková, Peter Deibert, M. Vecka, W.D. van Marken Lichtenbelt, A. Žák, Manfred W. Baumstark, J. Rambousková, V. Boschi, Jyotika Attri, Afig Huseyinov, Gerhard Rechkemmer, I. Knerr, P. D’Orsi, N. Margiotta, E. Tvrzická, Ingomar-Werner Franz, Karlis Briviba, F. Basile, O. Bellini, Achim Bub, Bernhard Watzl, D. Kubisová, M. Rauh, J. Fanta, P. Dlouhý, J. Pachl, Promila Pandhi, Andreas Berg, A. Oloo, M. Anděl, Aloys Berg, Safrun Mahmood, Meral Baka, C. Falconi, A. Ramel, I. Thorsdottir, Daniel König, G. Nasti, M. Siervo, G.A. Ettyang, Dominik Grathwohl, B. Staňková, Z. Straka, Mete Akisu, W.H.M. Saris, W. Rascher, H.K. Parwana, A. Papa, Nilgün Kültürsay, M. Gröschl, E. Trapanese, and Veena Dhawan

Subjects
Gerontology, medicine.medical_specialty, Medical education, Nutrition and Dietetics, business.industry, Acknowledgement, Alternative medicine, Medicine (miscellaneous), Medicine, business
Published
2003
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