1. Congenital Hypothyroidism due to a Low Level of Maternal Thyrotropin Receptor-Blocking Antibodies
- Author
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Véronique Raverot, Juliette Abeillon, Patricia Bretones, Myriam Moret, Solène Castellnou, Karim Chikh, Pauline Perrin, Fédération d’Endocrinologie, Maladies Métaboliques, Diabète et Nutrition [Bron] (FEMMDN/Hôpital Louis Pradel ), Hospices Civils de Lyon (HCL)-Groupement Hospitalier Est [Bron], Service d'endocrinologie pédiatrique [CHU Lyon-Hospices Civils de Lyon], Hospices Civils de Lyon (HCL), Service de Biochimie et Biologie Moléculaire Grand Est [HCL, Lyon] (Centre de Biologie et de Pathologie), Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre de Biologie et de Pathologie Sud [HCL, Lyon], and CarMeN, laboratoire
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medicine.medical_specialty ,TBAb ,endocrine system ,endocrine system diseases ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,[SDV]Life Sciences [q-bio] ,030209 endocrinology & metabolism ,Reference range ,Thyrotropin receptor ,03 medical and health sciences ,0302 clinical medicine ,Maternal hypothyroidism ,TSHR Ab ,Internal medicine ,medicine ,Thyrotropin receptor-blocking antibodies ,business.industry ,Thyroid ,medicine.disease ,Thyroid disorder ,3. Good health ,Congenital hypothyroidism ,[SDV] Life Sciences [q-bio] ,TRAb ,medicine.anatomical_structure ,Endocrinology ,030220 oncology & carcinogenesis ,Clinical Thyroidology / Case Report ,Thyroglobulin ,Thyroid function ,business ,hormones, hormone substitutes, and hormone antagonists - Abstract
Introduction: Maternal TSH receptor antibodies (TRAbs) can cross the placenta and affect fetal and neonatal thyroid function. Maternal TSH receptor-blocking antibodies (TBAbs) are a rare cause of congenital hypothyroidism. Case Report: Following the discovery of a highly elevated TSH on her neonatal screening test, a 10-day-old girl with no familial history of thyroid disorder was referred to the pediatric endocrinology unit. Hypothyroidism was confirmed with a highly elevated TSH (817 mIU/L, reference range 0.4–3.1) and very low levels of FT4 (1.8 pmol/L, reference range 12–22). Anti-TPO antibodies were at 81 IU/mL (reference range Conclusion: We report herein a case of transient congenital hypothyroidism with a normal neonatal TRAbs level. In case of maternal TBAbs, similar activity of maternal TBAbs must be expected in the neonate, independently of the neonatal level of TRAbs.
- Published
- 2020
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