1. The Association of Longitudinal Serum Uric Acid and All-Cause Mortality in Incident Peritoneal Dialysis Patients
- Author
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Xichao Wang, Shunya Uchida, Wenxiu Chang, Ying Liu, Yangke Tu, Yingying Han, and Wenyu Zhang
- Subjects
Adult ,Male ,medicine.medical_specialty ,Time Factors ,Adolescent ,medicine.medical_treatment ,030232 urology & nephrology ,Renal function ,Serum Albumin, Human ,030204 cardiovascular system & hematology ,Logistic regression ,Gastroenterology ,Peritoneal dialysis ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,Mortality ,Aged ,Retrospective Studies ,Aged, 80 and over ,business.industry ,Incidence ,Cholesterol, HDL ,Hazard ratio ,Albumin ,Hematology ,General Medicine ,Middle Aged ,Uric Acid ,C-Reactive Protein ,chemistry ,Nephrology ,Uric acid ,Female ,business ,Peritoneal Dialysis ,Body mass index ,All cause mortality - Abstract
Background: Time-averaged uric acid (TA-UA) value was calculated to investigate the association of longitudinal UA and all-cause mortality in incident peritoneal dialysis (PD) patients. Methods: Three hundred PD patients were divided into 3 groups based on the serum TA-UA level (Group 1: < 6 mg/dL; Group 2: 6–8 mg/dL; Group 3: ≥8 mg/dL). Hazards ratio (HR) of all-cause mortality was calculated. Logistic regression was conducted to identify the associated clinical factors of lower and higher TA-UA level. Results: Increased HRs for death existed in Group 1 and Group 3 compared with Group 2 (HR 3.24, 95% CI 1.25–8.39, p = 0.016; HR 4.69, 95% CI 1.24–17.72, p = 0.023). Lower residual renal function, lower albumin, and higher high-density lipoprotein cholesterol were related to the lower serum TA-UA. Higher body mass index and higher C-reactive protein were associated with higher serum TA-UA in PD patients. Conclusion: Both TA-UA < 6 and ≥8 mg/dL increased the all-cause mortality in incident PD patients.
- Published
- 2018