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1. IGICS: JGA Keynote Program. The 7th International Gastrointestinal Consensus Symposium (IGICS). Gastrointestinal Function and Diseases. February 15, 2014, CORASSE Fukushima, Japan: Abstracts

Author

Yuta Fuyuno, Kouichi Asano, Kosuke Nomura, Yasushi Adachi, Yuji Maehata, Hiroyoshi Kurihara, Akihiro Okazaki, Kei Mitsuhashi, Hiroyuki Yamamoto, Kozue Kanemitu, Tadashi Hasegawa, Takako Sasai, Takahisa Matsuda, Naoki Asayama, Ryusuke Kimura, Tadahiko Fuchigami, Tsukasa Furuhata, Shinji Tanaka, Fumiaki Hino, Hirokazu Yamagami, Shin Maeda, Mako Kamiya, Druckerei Stückle, Shuji Kochi, Mitsuyo Mieda, Hisayoshi Igarashi, Tomohiko Moriyama, Kazutomo Togashi, Taku Sakamoto, Yoshikazu Kinoshita, Hayato Sasaki, Hiroyuki Takamaru, Masanobu Yamada, Shin'ichi Takahashi, Takayuki Matsumoto, Yasutaka Sukawa, Junji Umeno, Jose D. Sollano, Ryoji Kushima, Ki Baik Hahm, Hironori Masuyama, Udom Kachintorn, Motohiro Esaki, Tetsuya Nakamura, Koichi Kurahara, Shinji Yoshii, Katsuhiko Nosho, Yoshihiro Izumi, Kohzoh Imai, Shinichi Kanno, Shotaro Nakamura, Koichi Hirata, Toshiro Iizuka, Hajime Amano, Abdul Aziz Rani, Keisuke Kawasaki, Nana Hayashi, Akira Terano, Yasuhisa Shinomura, Akiyo Kawada, Akira Matsui, Hideyuki Hiraishi, Tomohiro Nagasue, Yutaka Saito, Eriko So Tsuruki, Seiji Onogawa, Tetsuo Arakawa, Keiji Hanada, Kentaro Kurashina, Yasutaka Kuribayashi, Toru Zuiki, Seiichiro Abe, Akihiro Yamada, Yuji Naito, Juri Ikemoto, Haruka Fujinami, Motoyasu Kusano, Kenji Okita, Koichi Nakadoi, Yutaka Nagata, Francis K.L. Chan, Takayuki Ando, Masashi Mikami, Miki Ito, Shiro Oka, Koji Ikegami, Fumiaki Ueno, Kazuhiko Uchiyama, Yasuteru Urano, Makomo Makazu, Ari Fahrial Syam, Masayoshi Yamada, Hiroaki Takahashi, Shiko Kuribayashi, Mitsuru Kaise, Hiroki Yaita, Yoshio Katamura, Osamu Ogawa, Kwong Ming Fock, Hidekazu Suzuki, Takashi Joh, Norimiti Hirano, Hiroko Hosaka, Tomohisa Takagi, Satoshi Yamashita, Koji Arihiro, Osamu Kawamura, Hiromu Suzuki, Toshiro Sugiyama, Hironori Yamamoto, Toshifumi Mitani, Daisuke Kikuchi, Takaya Kusumi, Hiroshi Mihara, Hiroki Imagawa, Qi Zhu, Yoshinori Sato, Yasuyuki Shimoyama, Takeshi Kamiya, Chiko Sato, Takeshi Nakajima, Masato Shinzato, Shin Fukudo, Shinya Kajiura, Hirohito Tanaka, Naoto Yoshitake, Yuji Teraoka, Keijiro Sunada, Nobuaki Ikezawa, Reo Maruyama, Atsushi Masuyama, Masao Hosokawa, Kazuaki Chayama, Ayumu Hosokawa, Takanari Kitazono, and Shu Hoteya

Subjects
medicine.medical_specialty, business.industry, Family medicine, Gastroenterology, Medicine, business, Gastrointestinal function
Published
2015
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2. Relationship between the Degree of Endoscopic Atrophy of the Gastric Mucosa and Carcinogenic Risk

Author

Mitsuyo Mieda, Kazutomo Togashi, Tetsuya Nakamura, Kentaro Kurashina, Toru Zuiki, Naoto Yoshitake, Akira Terano, Takako Sasai, Hideyuki Hiraishi, Hironori Masuyama, Keijiro Sunada, Atsushi Masuyama, and Hironori Yamamoto

Subjects
Adult, Gastritis, Atrophic, Male, Risk, medicine.medical_specialty, Helicobacter pylori infection, Carcinogenesis, medicine.disease_cause, Gastroenterology, Endoscopy, Gastrointestinal, Helicobacter Infections, Atrophy, Predictive Value of Tests, Stomach Neoplasms, Internal medicine, medicine, Gastric mucosa, Humans, Carcinogen, Early Detection of Cancer, Aged, Aged, 80 and over, Original Paper, biology, Helicobacter pylori, business.industry, digestive, oral, and skin physiology, Cancer, Middle Aged, medicine.disease, biology.organism_classification, digestive system diseases, medicine.anatomical_structure, Gastric Mucosa, Female, Gastritis, medicine.symptom, business
Abstract

Background: The relationship between Helicobacter pylori infection and gastric cancer has been demonstrated, and the risk of gastric cancer occurrence is known to increase with the progression of atrophic changes associated with chronic gastritis. Endoscopic evaluation of the degree and extent of atrophy of the gastric mucosa is a simple and very important means of identifying a group at high risk for gastric cancer. This study aimed to clarify the carcinogenic risk in relation to the degree of atrophy. Methods: A total of 27,777 patients (272 with early gastric cancer and 135 with advanced gastric cancer) were included in this study. Endoscopically evaluated atrophy of the gastric mucosa was classified as C-0 to O-3 according to the Kimura and Takemoto classification system. Results: The cancer detection rate in relation to the degree of gastric mucosal atrophy was 0.04% (2/4,183 patients) for C-0, 0% (0/4,506) for C-1, 0.25% (9/3,660) for C-2, 0.71% (21/2,960) for C-3, 1.32% (75/5,684) for O-1, 3.70% (140/3,780) for O-2 and 5.33% (160/3,004) for O-3. As to the proportions of differentiated and undifferentiated cancers, the latter were relatively frequent in the C-0 to C-2 groups, but differentiated cancers became predominant as atrophy progressed. On the other hand, the number of both differentiated and undifferentiated cancers detected increased as gastric mucosal atrophy progressed. In addition, open-type atrophy was found in 29 (96.7%) of 30 patients with synchronous multiple gastric cancers and in all 20 patients with metachronous multiple gastric cancers. Conclusion: Endoscopic evaluation of gastric mucosal atrophy can provide a simple and reliable predictive index for both current and future carcinogenic risk.

Published
2015

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