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1. Accidental Ingestion of Allergic Food at Eating-Out and Home Meal Replacement by Children with Food Allergy

Author

Takanori Imai

Subjects
Immunology, Immunology and Allergy, General Medicine
Abstract

Introduction: In Japan, there are no regulations for allergy labeling in eating-out and home meal replacement (HMR). Consequently, patients with food allergy are at risk of accidental ingestion when using these services. It is necessary to understand the current situation of accidental food ingestion at eating-out and HMR to consider related legislation in the future. Methods: A Web-based survey was conducted from August to September 2021 among patients participating in the survey. The survey included information on the use of eating-out and HMR, frequency of accidental ingestion, medical institution visits and treatment, and reasons for accidental ingestion. Results: There were 1,141 valid responses, with 8 (5–15) years as the median age of the participants. Moreover, 769 (67.4%) participants had a history of anaphylaxis, 622 (54.5%) experienced accidental ingestion, of which 485 (42.5%) and 348 (30.6%) occurred while eating-out and at HMR, respectively. A total of 71 (14.6%) and 31 (8.9%) participants who had accidental ingestion while eating-out and at HMR, respectively, required hospitalization. Age, milk allergy, and a history of anaphylaxis were risk factors significantly associated with accidental ingestion. The reasons for the accidental ingestions were personal and store-side error for a total of 438 cases and of 356 cases, respectively. Discussion/Conclusion: It is necessary for both stores and patients to take measures to prevent accidental ingestion in eating-out and HMR. Additionally, the fact is that the lack of allergy labeling guidelines for eating-out and HMR is a major factor in the occurrence of accidental ingestion.

Published
2023
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2. Predictors of Persistent Wheat Allergy in Children: A Retrospective Cohort Study

Author

Tomoyuki Asaumi, Kiyotaka Ohtani, Sakura Sato, Noriyuki Yanagida, Kiyotake Ogura, Takanori Imai, Motohiro Ebisawa, and Yumi Koike

Subjects
Male, medicine.medical_specialty, Immunology, Wheat Hypersensitivity, Immunoglobulin E, 03 medical and health sciences, 0302 clinical medicine, Food allergy, Internal medicine, Immune Tolerance, medicine, Humans, Immunology and Allergy, 030212 general & internal medicine, Child, Triticum, Retrospective Studies, chemistry.chemical_classification, biology, Oral food challenge, business.industry, Infant, food and beverages, Anaphylactic reactions, Retrospective cohort study, General Medicine, medicine.disease, Gluten, 030228 respiratory system, chemistry, Child, Preschool, biology.protein, Female, business, Wheat allergy, Anaphylaxis
Abstract

Background: Wheat allergy is the third most common food allergy that develops during infancy in Japan. To identify factors associated with persistent wheat allergy, we assessed the rate of tolerance acquisition among Japanese children aged less than 6 years with an immediate-type wheat allergy using the oral food challenge (OFC) method. Methods: This retrospective cohort study included 83 children (born in 2005–2006) who had a history of immediate-type allergic reaction to wheat and were followed until 6 years of age. The subjects were divided to form “tolerant” (n = 55; tolerance acquired by 6 years of age) and “allergic” (n = 28; tolerance not acquired by 6 years of age) groups based on their OFC results. Results: The rates of tolerance acquisition to 200 g of udon noodles at 3, 5, and 6 years of age were 20.5% (17/83), 54.2% (45/83), and 66.3% (55/83), respectively. The total number of anaphylactic reactions experienced prior to 3 years of age in response to all foods (p < 0.01) and to wheat (p = 0.043) was significantly higher in the allergic than in the tolerant group. Wheat- and ω-5 gliadin-specific immunoglobulin E (IgE) levels were significantly higher in the allergic group than in the tolerant group (p < 0.01), and wheat-specific IgE levels were more likely to increase after infancy in the allergic group. Conclusions: A history of anaphylaxis to all foods including wheat and/or a high level of wheat- or ω-5 gliadin-specific IgE antibodies were identified as risk factors for persistent wheat allergy.

Published
2018
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3. Utility of the Peripheral Blood Basophil Histamine Release Test in the Diagnosis of Hen’s Egg, Cow’s Milk, and Wheat Allergy in Children

Author

Takatsugu Komata, Akinori Shukuya, Morimitsu Tomikawa, Takanori Imai, Sakura Sato, Mika Ogata, Hiroshi Tachimoto, and Motohiro Ebisawa

Subjects
Male, Immunology, Basophil degranulation test, Administration, Oral, Basophil Degranulation Test, Wheat Hypersensitivity, Immunologic Tests, Biology, Basophil, Histamine Release, Sensitivity and Specificity, behavioral disciplines and activities, Dermatitis, Atopic, chemistry.chemical_compound, Food allergy, Prohibitins, mental disorders, medicine, Humans, Immunology and Allergy, In patient, Child, Egg Hypersensitivity, Oral food challenge, digestive, oral, and skin physiology, General Medicine, Allergens, Immunoglobulin E, medicine.disease, Asthma, Peripheral blood, Antibodies, Anti-Idiotypic, medicine.anatomical_structure, ROC Curve, nervous system, chemistry, Child, Preschool, Female, Milk Hypersensitivity, psychological phenomena and processes, Histamine, Wheat allergy
Abstract

Background: The diagnosis of food allergy (FA) is made by oral food challenge tests (OFCs) that occasionally produce serious symptoms in patients; therefore, whether to perform OFCs should be carefully considered. The utility of the histamine release test (HRT) in the diagnosis of childhood FA has not been fully examined. Methods: Sixty-four subjects with suspected hen’s egg allergy, cow’s milk allergy (CMA), and wheat allergy (WA) were enrolled. The diagnosis of FA was made based on the outcomes of OFCs or a convincing history of symptoms after food ingestion within 6 months before or after sample collection. HRT was performed using an HRT Shionogi kit. The threshold of histamine release (HRT threshold), which was defined as the minimum concentration of food antigen to induce a 10% net histamine release, was analyzed in association with FA diagnosis. Results: Receiver operating characteristic analysis showed that the HRT threshold was useful in the diagnosis of heated egg allergy (HEA), raw egg allergy (REA), CMA, and WA. We were able to determine the cutoff value for the HRT threshold in relation to outcomes of OFCs. The cutoff value was 6 ng/ml of egg white antigen in HEA and REA (p < 0.01), 40 ng/ml of milk antigen in CMA (p < 0.01), and 500 ng/ml of wheat antigen in WA (p < 0.05). The efficiency was 70.3% for HEA, 78.0% for REA, 77.6% for CMA, and 70.7% for WA. Conclusions: We conclude that the HRT threshold measurement for egg white, milk, and wheat antigen is related to outcomes of OFCs and is useful in determining when OFCs should be performed.

Published
2011
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4. Nationwide Food Allergy Survey

Author

Takanori Imai, Y. Iikura, and A. Akasawa

Subjects
Allergy, medicine.diagnostic_test, biology, business.industry, Radioallergosorbent test, Immunology, General Medicine, medicine.disease, Immunoglobulin E, medicine.disease_cause, Allergen, Food allergy, Immunopathology, medicine, biology.protein, Immunology and Allergy, Adverse effect, business, Anaphylaxis
Abstract

We investigated cases of anaphylaxis caused by an adverse reaction to food from major hospitals with over 200 beds across the country. These cases showed anaphylactic symptoms within 60 min after the

Published
2001
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5. Abstracts of Lectures at the Workshop

Author

Shuhei Fukuda, Masaya Yokota, Yuko Nakase, Sakura Sato, Takatsugu Komata, Hiroshi Uchi, Masutaka Furue, Ryuji Sato, Masahide Takeda, Isao Ohno, Kinya Nagata, Hiroyuki Nagase, Hiroyuki Hirai, Hiroyuki Ida, Satoshi Matsukura, Shintaro Suzuki, Druck Reinhardt Druck Basel, Yukiko Hiraguchi, Kenichi Maruyama, Takayuki Ohtomo, Koichiro Asano, Akira Nishi, Hiroshi Moriyama, Toshio Inoue, Takashi Iwanaga, Gail M. Kephart, Yusuke Suzuki, Akio Mori, Daiki Nakagomi, Motohiro Ebisawa, Takahiro Tsuburai, Naoya Sugimoto, Akemi Abe, Chisei Ra, Hirohito Kita, Shu Hashimoto, Takahito Chiba, Tasuku Kawano, Shu Imbe, Morimitsu Tomikawa, Shizuko Kagawa, Kotaro Suzuki, Mio Kawaguchi, Takachika Hiroi, Ichiro Nomura, Satz Mengensatzproduktion, Sho Matsushita, Mika Ogata, Kota Wada, Hidefumi Wakashin, Noriko Kitamura, Hiroshi Santo, Motoaki Takayanagi, Junji Yodoi, Katsuhito Iikura, Koa Hosoki, Toshiaki Kikuchi, Kazuma Iida, Reiko Tokuda, Tetsuya Shiomi, Hirohisa Saito, Takao Fujisawa, Koichi Sayama, Noriko Kobayashi, Fumiko Yasukawa, Toshio Katsunuma, Makiko Fukunaga, Naomi Tsurikisawa, Masataka Nakamura, Kosei Iguchi, Eiko Ito, Kazuo Ishikawa, Maho Suzukawa, Hirotoshi Kawashima, Makoto Nagata, Chikara Asaka, Saburo Saito, Mino Yoshioka, Yoshiyuki Yamada, Mizuho Nagao, Yasuhide Hayashi, Hiroko Takeuchi, Masao Yamaguchi, Naoko Fukui, Kaori Okuyama, Yuka Hamanaka, Hiroyuki Sano, Wataru Ito, Hideki Tatsumi, Soichi Nemoto, Takanori Imai, Chiyako Oshikata, Yuichi Ohkawara, Yasuhiro Gon, Kaiyu Han, Kazuo Akiyama, Masayuki Sato, Ken Ohta, Toshiaki Ihara, Yuji Tohda, Satoshi Koyama, Takehiro Higashi, Hiroshi Tachimoto, Noriko Hashimoto, Shin-itsu Hatakeyama, Tokuhiro Kimura, Junko Hirato, Rie Takagi, Kohei Honda, Yoshinori Matsuwaki, Masatsugu Kurokawa, Masamune Higashigawa, Hisashi Tanida, Koushi Ieki, Osamu Kaminuma, Kumiko Hashimoto, Takako Toda, Shigeharu Ueki, Hiroshi Nakajima, Hideki Yamamoto, Tetsuya Homma, Koichi Fukunaga, Munehiro Yamaguchi, Masahiko Kato, Shin Watanabe, Norio Suzuki, Miho Odaka, Akinori Shukuya, Yoshifumi Ebara, Mitsuru Adachi, Hiroaki Takatori, Arifumi Iwata, Hiroyuki Kayaba, Hiroshi Saito, Masato Muraki, Satoshi Nunomura, Kenji Matsumoto, Sadato Ichinohe, Hajime Nakamura, Junichi Chihara, Tsuyoshi Oguma, Hideaki Morita, and Shizuko Saika

Subjects
business.industry, Immunology, Immunology and Allergy, Medicine, General Medicine, business
Published
2011
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6. Subject Index Vol. 155, Suppl. 1, 2011

Author

Kinya Nagata, Satoshi Matsukura, Hiroshi Moriyama, Koichiro Asano, Kohei Honda, Yoshinori Matsuwaki, Takashi Iwanaga, Yusuke Suzuki, Gail M. Kephart, Akio Mori, Hiroyuki Kayaba, Morimitsu Tomikawa, Shin-itsu Hatakeyama, Shigeharu Ueki, Shizuko Kagawa, Takachika Hiroi, Tokuhiro Kimura, Koichi Fukunaga, Hiroshi Nakajima, Arifumi Iwata, Sakura Sato, Takatsugu Komata, Mika Ogata, Masahide Takeda, Daiki Nakagomi, Munehiro Yamaguchi, Kenji Matsumoto, Masutaka Furue, Akinori Shukuya, Chiyako Oshikata, Kazuo Akiyama, Takahito Chiba, Mino Yoshioka, Kenichi Maruyama, Noriko Kobayashi, Makoto Nagata, Toshiaki Ihara, Mizuho Nagao, Kaori Okuyama, Hiroshi Saito, Yukiko Hiraguchi, Chikara Asaka, Hiroyuki Hirai, Hiroyuki Ida, Toshio Inoue, Reiko Tokuda, Takao Fujisawa, Motohiro Ebisawa, Saburo Saito, Takayuki Ohtomo, Satz Mengensatzproduktion, Hiroyuki Sano, Koa Hosoki, Naoya Sugimoto, Kazuma Iida, Takako Toda, Masao Yamaguchi, Tetsuya Shiomi, Hiroko Takeuchi, Eiko Ito, Akira Nishi, Kaiyu Han, Kosei Iguchi, Junji Yodoi, Katsuhito Iikura, Naomi Tsurikisawa, Yuka Hamanaka, Sadato Ichinohe, Mio Kawaguchi, Hirotoshi Kawashima, Norio Suzuki, Yasuhide Hayashi, Masataka Nakamura, Mitsuru Adachi, Rie Takagi, Shintaro Suzuki, Druck Reinhardt Druck Basel, Soichi Nemoto, Ichiro Nomura, Noriko Kitamura, Kotaro Suzuki, Tasuku Kawano, Motoaki Takayanagi, Hirohito Kita, Noriko Hashimoto, Hirohisa Saito, Shu Imbe, Masato Muraki, Fumiko Yasukawa, Hidefumi Wakashin, Hiroshi Uchi, Kota Wada, Makiko Fukunaga, Satoshi Koyama, Masayuki Sato, Takehiro Higashi, Toshio Katsunuma, Sho Matsushita, Toshiaki Kikuchi, Hiroshi Santo, Tetsuya Homma, Koichi Sayama, Takahiro Tsuburai, Takanori Imai, Yuichi Ohkawara, Yasuhiro Gon, Kazuo Ishikawa, Shuhei Fukuda, Osamu Kaminuma, Kumiko Hashimoto, Wataru Ito, Hideki Tatsumi, Hiroshi Tachimoto, Hiroyuki Nagase, Ken Ohta, Junko Hirato, Hajime Nakamura, Isao Ohno, Shu Hashimoto, Junichi Chihara, Satoshi Nunomura, Tsuyoshi Oguma, Shin Watanabe, Hiroaki Takatori, Hideaki Morita, Akemi Abe, Chisei Ra, Shizuko Saika, Maho Suzukawa, Koushi Ieki, Masahiko Kato, Miho Odaka, Yoshifumi Ebara, Masaya Yokota, Yuko Nakase, Ryuji Sato, Yuji Tohda, Hisashi Tanida, Masatsugu Kurokawa, Masamune Higashigawa, Hideki Yamamoto, Yoshiyuki Yamada, and Naoko Fukui

Subjects
Gerontology, Index (economics), business.industry, Immunology, Immunology and Allergy, Medicine, Subject (documents), General Medicine, business
Published
2011
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7. Dolphin-Assisted Seawater Therapy for Severe Atopic Dermatitis: An Immunological and Psychological Study

Author

T. Matsuoka, M. Tomikawa, M. Utumi, Y. Iikura, Y. Sakamoto, K. Sugihara, L. Akai, and Takanori Imai

Subjects
Allergy, Eosinophil cationic protein, Bathing, business.industry, medicine.medical_treatment, Immunology, General Medicine, Atopic dermatitis, medicine.disease, Atopy, Immunopathology, Immunology and Allergy, Medicine, Interleukin 8, business, Hydrotherapy, human activities
Abstract

We performed seawater therapy on atopic dermatitis patients for 6 days with dolphins. The presence of the dolphins seemed to alleviate the pain patients experienced while bathing in seawater. The skin condition improved dramatically, and immunologically, serum IL-8 levels decreased but MIP-1α and eosinophil cationic protein did not change.

Published
2001
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8. List of Lectures

Author

Nobufumi Kamiishi, Koichi Hirose, Shin-ichiro Kagami, Sakura Sato, Motohiro Kodama, Takehiko Sasaki, Akinori Shukuya, Kenji Matsumoto, Satoshi Nunomura, Shoichiro Miyatake, Robert P. Schleimer, Masahide Takeda, Jun Miyata, Tadashi Terui, Soichi Nemoto, Daisuke Kashiwakuma, Shintaro Suzuki, Yoshiyuki Yamada, Taku Miyasho, Satoshi Matsukura, Akemi Abe, Takehito Kobayashi, Koichiro Asano, Shin Watanabe, Teruaki Kimura, Miho Odaka, Noriaki Kobayashi, Kotaro Suzuki, Morimitsu Tomikawa, Shizuko Kagawa, Takachika Hiroi, Hiromi Ogura, Masatsugu Kurokawa, Tsukasa Ohnishi, Akio Mori, Hiroyuki Miyoshi, Takayuki Ohtomo, Katsuyoshi Tomomatsu, Yukiko Hiraguchi, Shunsuke Furuta, Hideo Wada, Yotaro Takaku, Misa Wakaki, Eiji Ikeda, Hikari Kato, Yoshihiro Oya, Hiroyuki Kayaba, Jose A. Cancelas, Kazuya Suzuki, Koushi Ieki, Mio Kawaguchi, Yasuhide Hayashi, Shuichi Yamamoto, Koichi Hagiwara, Chisei Ra, Takefumi Yamaguchi, Shuhei Fukuda, Takao Fujisawa, Tomohiro Utsunomiya, Itsuo Iwamoto, Osamu Kaminuma, Junji Yamada, Kei Ikeda, Tomomi Tanigai, Koichi Fukunaga, Makoto Nagata, Yoshitaka Okamoto, Hiroshi Tachimoto, Matsunobu Suko, Koa Hosoki, Takashi Hirose, Fujiko Kitamura, Tetsuya Homma, Maki Terakawa, Norimasa Kurosaka, Wataru Ito, Hiroko Kanari, Masako Tanabe, Hideki Tatsumi, Junichi Chihara, Tsuyoshi Oguma, Masamichi Iguchi, Yuko Kitahata, Kyuto Tanaka, Reiko Tokuda, Koichi Sayama, Akira Suto, Masayuki Sato, Kazuyuki Nakagome, Masahiko Kato, Motohiro Ebisawa, Soichiro Ueda, Noriyuki Yanagida, Akiko Nakamura, Takatsugu Komata, Fuyumi Nishihara, Minoru Kanazawa, Mizuho Nagao, Takanori Imai, Takahisa Takihara, Junko Kihara, Mitsuru Adachi, Norihiko Watanabe, Tsutomu Nobori, Nao Ohmori, Shigeharu Ueki, Hiroshi Nakajima, Kenichi Maruyama, Noriko Kitamura, Hirohisa Saito, Tomoyuki Soma, and Akitoshi Ishizaka

Subjects
business.industry, Immunology, Immunology and Allergy, Medicine, General Medicine, business
Published
2010
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9. Subject Index Vol. 152, Suppl. 1, 2010

Author

Kyuto Tanaka, Reiko Tokuda, Masamichi Iguchi, Daisuke Kashiwakuma, Tomoyuki Soma, Itsuo Iwamoto, Koichi Fukunaga, Teruaki Kimura, Hiromi Ogura, Koichi Hagiwara, Masatsugu Kurokawa, Akinori Shukuya, Masahiko Kato, Takehito Kobayashi, Yasuhide Hayashi, Soichiro Ueda, Satoshi Matsukura, Sakura Sato, Takatsugu Komata, Matsunobu Suko, Fuyumi Nishihara, Hiroko Kanari, Motohiro Ebisawa, Koichiro Asano, Eiji Ikeda, Masayuki Sato, Misa Wakaki, Yukiko Hiraguchi, Junichi Chihara, Yoshihiro Oya, Tsuyoshi Oguma, Tadashi Terui, Koichi Sayama, Noriaki Kobayashi, Nobufumi Kamiishi, Satoshi Nunomura, Mitsuru Adachi, Tsutomu Nobori, Akira Suto, Tsukasa Ohnishi, Akio Mori, Noriko Kitamura, Hideo Wada, Shuichi Yamamoto, Yotaro Takaku, Hirohisa Saito, Takefumi Yamaguchi, Hiroyuki Kayaba, Jose A. Cancelas, Miho Odaka, Takao Fujisawa, Junji Yamada, Chisei Ra, Mizuho Nagao, Hikari Kato, Takanori Imai, Kei Ikeda, Takehiko Sasaki, Osamu Kaminuma, Hiroyuki Miyoshi, Shoichiro Miyatake, Nao Ohmori, Wataru Ito, Hideki Tatsumi, Hiroshi Tachimoto, Tetsuya Homma, Koa Hosoki, Katsuyoshi Tomomatsu, Kotaro Suzuki, Takashi Hirose, Kenji Matsumoto, Tomohiro Utsunomiya, Kazuyuki Nakagome, Kazuya Suzuki, Yuko Kitahata, Tomomi Tanigai, Shigeharu Ueki, Maki Terakawa, Shin Watanabe, Yoshitaka Okamoto, Hiroshi Nakajima, Fujiko Kitamura, Norimasa Kurosaka, Masako Tanabe, Kenichi Maruyama, Shintaro Suzuki, Shuhei Fukuda, Koichi Hirose, Makoto Nagata, Shunsuke Furuta, Motohiro Kodama, Shin-ichiro Kagami, Yoshiyuki Yamada, Taku Miyasho, Koushi Ieki, Morimitsu Tomikawa, Akitoshi Ishizaka, Shizuko Kagawa, Takachika Hiroi, Akemi Abe, Takayuki Ohtomo, Mio Kawaguchi, Robert P. Schleimer, Masahide Takeda, Jun Miyata, Soichi Nemoto, Takahisa Takihara, Junko Kihara, Norihiko Watanabe, Noriyuki Yanagida, Akiko Nakamura, and Minoru Kanazawa

Subjects
Gerontology, Index (economics), Immunology, Immunology and Allergy, Subject (documents), General Medicine, Psychology
Published
2010
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10. Frequency of Immediate–Type Food Allergy in Children in Japan

Author

Kazunobu Fujita, Y. Imai, K. Koike, Yasurou Kohno, E. Iwasaki, Takanori Imai, H. Nakura, K. Hoshiyama, H. Okudaira, Yoji Iikura, and A. Akasawa

Subjects
medicine.medical_specialty, Allergy, Pediatrics, business.industry, Public health, Immunology, General Medicine, Allergens, medicine.disease, Japan, Food allergy, Child, Preschool, Surveys and Questionnaires, Environmental health, Immunopathology, Epidemiology, Humans, Immunology and Allergy, Medicine, Sea food, business, Food Hypersensitivity
Published
1999
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