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1. Complete Contents Vol. 17, 2001

Author

Frank Dobrowolski, Jakob R. Izbicki, Wolfram Domschke, Julia Mayerle, Hans Lippert, P. Aleman, M. González Valverde, Helmut Friess, M.W. Müller, R. Grote, H. Fischer, V. Garcia-Medina, Manfred V. Singer, Jürgen Schnekenburger, D. Ockert, J.D. Berna, Joachim Mössner, A.A. Tempia-Caliera, R.M. Grabs, A.M. Müller, Stephan Kersting, Peter Simon, René Mantke, Matthias P. Ebert, B. Glasbrenner, Wolfram T. Knoefel, S. Kahl, A. Leodolter, Hans-Detlev Saeger, Peter Malfertheiner, J.-M. Löhr, M. Madrigal, Jürgen F. Riemann, M. Senkal, Hans-Ulrich Schulz, Tim Strate, Rene Hennig, Markus M. Lerch, Ralf Jakobs, M. Pross, M.W. Büchler, and Frank-Ulrich Weiss

Subjects
Gastroenterology, Surgery
Published
2001

2. Chronische Pankreatitis: Pathogenese, molekulare Pathophysiologie und genetische Veränderungen

Author

Frank-Ulrich Weiss, Wolfram Domschke, Peter Simon, Markus M. Lerch, Julia Mayerle, and Jürgen Schnekenburger

Subjects
medicine.medical_specialty, Pathology, business.industry, Gastroenterology, Alcohol abuse, medicine.disease, Pathophysiology, Pathogenesis, Treatment modality, Internal medicine, medicine, Pancreatitis, Surgery, Disease process, business, Alcohol consumption
Abstract

Chronic Pancreatitis: Pathogenesis, Molecular Pathophysiology, and Genetic Changes Most cases of chronic pancreatitis are caused by immoderate alcohol consumption or alcohol abuse. The type of alcoholic beverage that is being excessively consumed, on the other hand, appears to be immaterial for the onset of pancreatitis. Over the last decade a number of pathophysiological, biochemical and genetic studies have permitted a better understanding of the pathogenetic basis of chronic pancreatitis. This elucidation of the molecular mechanisms involved in the disease process will most probably lead to the development of causal treatment modalities – although none is available so far. Here we review the latest developments and research results that have addressed the pathogenesis of chronic pancreatitis.

Published
2001

3. Band 17, Heft 4, December 2001

Author

J.-M. Löhr, R. Grote, Markus M. Lerch, Hans Lippert, A.M. Müller, M.W. Müller, P. Aleman, Jürgen Schnekenburger, Wolfram T. Knoefel, V. Garcia-Medina, R.M. Grabs, M. González Valverde, M. Pross, A.A. Tempia-Caliera, M.W. Büchler, Joachim Mössner, Matthias P. Ebert, Frank Dobrowolski, Peter Simon, René Mantke, M. Senkal, Wolfram Domschke, J.D. Berna, S. Kahl, H. Fischer, A. Leodolter, Frank-Ulrich Weiss, Jakob R. Izbicki, Manfred V. Singer, Julia Mayerle, M. Madrigal, B. Glasbrenner, Ralf Jakobs, Peter Malfertheiner, Hans-Ulrich Schulz, Hans-Detlev Saeger, Jürgen F. Riemann, Helmut Friess, Stephan Kersting, Tim Strate, Rene Hennig, and D. Ockert

Subjects
Gastroenterology, Surgery
Published
2001

4. Jahresinhalt Band 17, 2001

Author

Hans-Detlev Saeger, Jakob R. Izbicki, Manfred V. Singer, Julia Mayerle, Ralf Jakobs, P. Aleman, Helmut Friess, René Mantke, H. Fischer, Markus M. Lerch, B. Glasbrenner, V. Garcia-Medina, Tim Strate, Rene Hennig, M.W. Müller, Stephan Kersting, M. Madrigal, M. Pross, J.-M. Löhr, M.W. Büchler, Hans Lippert, Peter Malfertheiner, S. Kahl, Joachim Mössner, Hans-Ulrich Schulz, Frank Dobrowolski, M. Senkal, Jürgen Schnekenburger, Frank-Ulrich Weiss, R.M. Grabs, Jürgen F. Riemann, J.D. Berna, Wolfram Domschke, R. Grote, M. González Valverde, A.M. Müller, D. Ockert, Wolfram T. Knoefel, Matthias P. Ebert, A. Leodolter, A.A. Tempia-Caliera, and Peter Simon

Subjects
Gastroenterology, Surgery
Published
2001

5. Inhalt Band 16, 2000

Author

D. Kröber, H.F. Otto, M. Ulrich, D. Katenkamp, B. Walzel, U. C. Leutloff, G. Nöldge, C.-G. Schmedt, Reinhard Bittner, T. Pohle, B.J. Leibl, H. Bosseckert, K. Kraft, B. Werner, G. M. Richter, E. Remmel, G. Boden, F. Harder, R. Arbogast, I. Braun-Anhalt, J. Scheele, F. Autschbach, K. Pinnisch, Norbert Senninger, Jochen Hansmann, Markus M. Lerch, G. W. Kauffmann, U. Gottschalk, U. Will, Wolfram Domschke, G. Schürmann, T. Kocher, A. Flor, A. Tuchmann, and C. Emparan

Subjects
Gastroenterology, Surgery
Published
2000

6. Band 16, Heft 4, Dezember 2000

Author

C. Emparan, K. Pinnisch, K. Kraft, R. Arbogast, A. Tuchmann, T. Kocher, G. Boden, E. Remmel, A. Flor, H. Bosseckert, Markus M. Lerch, H.F. Otto, Reinhard Bittner, D. Katenkamp, M. Ulrich, J. Scheele, B.J. Leibl, Norbert Senninger, G. W. Kauffmann, F. Autschbach, G. Nöldge, U. Gottschalk, F. Harder, Jochen Hansmann, Wolfram Domschke, B. Werner, D. Kröber, G. M. Richter, C.-G. Schmedt, G. Schürmann, T. Pohle, U. C. Leutloff, I. Braun-Anhalt, B. Walzel, and U. Will

Subjects
Gastroenterology, Surgery
Published
2000

7. Immunohistochemical Distribution and Serum Levels of the Ca2+ -Binding Proteins MRP8, MRP14 and Their Heterodimeric Form MRP8/14 in Crohn’s Disease

Author

Wolfram Domschke, Clemens Sorg, Torsten Kucharzik, Guri Rohlmann, Norbert Lügering, Kurt Werner Schmid, Gerd Burmeister, and R. Stoll

Subjects
Crohn's disease, medicine.diagnostic_test, business.industry, medicine.drug_class, Binding protein, Gastroenterology, medicine.disease, Monoclonal antibody, Epitope, Calcium-binding protein, Immunoassay, Immunology, Medicine, Immunohistochemistry, Distribution (pharmacology), business
Abstract

In previous histochemical studies the distribution of the two Ca2+-binding proteins MRP8 and MRP 14 as well as their heterocomplex MRP8/14 has been demonstrated in different inflammatory diseases. Monoclonal antibodies against MRP8 and MRP14 and their heterodimer MRP8/14 (27E10 epitope) were used to investigate immunohistochemically the distribution of these proteins in routinely processed small and large bowel tissues from patients with Crohn’s disease (CD). Furthermore, we used a sandwich immunoassay to measure serum concentrations of MRPs in 62 patients with CD and in 20 healthy controls. Disease activities of CD patients were simultaneously assessed by the Crohn’s disease activity index (CDAI) and the severity activity index of Goebell (SAI). In our immunohistochemical study, MRP8, MRP 14 and the heterocomplex MRP8/14 were demonstrated in the majority of granulocytes and macrophages in active CD. Additionally, a strong complex MRP8/14 immunoreactivity was present in epithelial cells adjacent to ulcer-ative and fissuring lesions in the bowel. Serum MRP 8/14 concentrations were significantly (p 150, SAI > 120). No correlations were found for level of MRP 14 and MRP8 alone, respectively. The follow-up of individual patients with initially active CD showed a further increase in MRP8/14 levels during acute attacks of the inflammatory process. We suggest that our assay for MRP8/14 discriminates well between active and inactive CD and may have considerable potential in the analysis of clinical disease activity in CD patients. Our morphological results confirm the finding of increased MRP8/14 serum levels in patients with active CD.

Published
1995

8. Sachwortverzeichnis Band 17, 2001

Author

Hans-Detlev Saeger, Jürgen F. Riemann, A. Leodolter, A.A. Tempia-Caliera, Peter Simon, Wolfram T. Knoefel, Hans Lippert, Helmut Friess, Jürgen Schnekenburger, Markus M. Lerch, S. Kahl, M.W. Müller, Jakob R. Izbicki, Stephan Kersting, Julia Mayerle, D. Ockert, Wolfram Domschke, Frank-Ulrich Weiss, M. Madrigal, M. González Valverde, J.D. Berna, J.-M. Löhr, R.M. Grabs, Frank Dobrowolski, H. Fischer, V. Garcia-Medina, Ralf Jakobs, Matthias P. Ebert, Manfred V. Singer, B. Glasbrenner, P. Aleman, M.W. Büchler, Joachim Mössner, René Mantke, Peter Malfertheiner, Hans-Ulrich Schulz, Tim Strate, Rene Hennig, M. Senkal, R. Grote, A.M. Müller, and M. Pross

Subjects
Gastroenterology, Surgery
Published
2001

9. Subject Index Vol. 17, 2001

Author

M.W. Büchler, J.-M. Löhr, Wolfram T. Knoefel, Helmut Friess, Markus M. Lerch, Ralf Jakobs, Stephan Kersting, H. Fischer, M.W. Müller, Jürgen F. Riemann, D. Ockert, Hans-Detlev Saeger, Frank-Ulrich Weiss, Jakob R. Izbicki, Julia Mayerle, Wolfram Domschke, M. Madrigal, J.D. Berna, M. González Valverde, R.M. Grabs, Tim Strate, Manfred V. Singer, Rene Hennig, V. Garcia-Medina, S. Kahl, Frank Dobrowolski, Matthias P. Ebert, B. Glasbrenner, M. Pross, A.A. Tempia-Caliera, Peter Simon, P. Aleman, A. Leodolter, Hans Lippert, Jürgen Schnekenburger, Peter Malfertheiner, Hans-Ulrich Schulz, René Mantke, M. Senkal, R. Grote, A.M. Müller, and Joachim Mössner

Subjects
Index (economics), Statistics, Gastroenterology, Surgery, Subject (documents), Mathematics
Published
2001

10. Author Index Vo. 16, 2000 · Autorenverzeichnis Band 16, 2000

Author

G. W. Kauffmann, Reinhard Bittner, A. Flor, C.-G. Schmedt, B. Werner, B. Walzel, T. Pohle, U. C. Leutloff, G. M. Richter, Wolfram Domschke, K. Pinnisch, E. Remmel, M. Ulrich, J. Scheele, U. Gottschalk, Norbert Senninger, D. Katenkamp, C. Emparan, H.F. Otto, G. Nöldge, I. Braun-Anhalt, R. Arbogast, K. Kraft, G. Boden, F. Harder, Jochen Hansmann, B.J. Leibl, G. Schürmann, T. Kocher, H. Bosseckert, Markus M. Lerch, A. Tuchmann, U. Will, D. Kröber, and F. Autschbach

Subjects
Index (economics), Statistics, Gastroenterology, Surgery, Mathematics
Published
2000

11. Sachwortverzeichnis Band 16, 2000

Author

G. W. Kauffmann, A. Flor, U. C. Leutloff, K. Pinnisch, Norbert Senninger, T. Pohle, D. Kröber, B. Werner, B.J. Leibl, Reinhard Bittner, R. Arbogast, B. Walzel, M. Ulrich, C.-G. Schmedt, G. M. Richter, F. Autschbach, C. Emparan, G. Schürmann, F. Harder, D. Katenkamp, E. Remmel, H. Bosseckert, G. Nöldge, I. Braun-Anhalt, Jochen Hansmann, J. Scheele, Wolfram Domschke, K. Kraft, U. Gottschalk, G. Boden, H.F. Otto, T. Kocher, Markus M. Lerch, U. Will, and A. Tuchmann

Subjects
Gastroenterology, Surgery
Published
2000

12. Subject Index Vol.16, 2000

Author

C. Emparan, Wolfram Domschke, G. M. Richter, T. Kocher, K. Pinnisch, Reinhard Bittner, J. Scheele, G. W. Kauffmann, C.-G. Schmedt, M. Ulrich, T. Pohle, G. Schürmann, Markus M. Lerch, H.F. Otto, I. Braun-Anhalt, K. Kraft, E. Remmel, U. Will, U. Gottschalk, G. Boden, Norbert Senninger, R. Arbogast, A. Flor, H. Bosseckert, B.J. Leibl, U. C. Leutloff, A. Tuchmann, F. Harder, Jochen Hansmann, F. Autschbach, D. Kröber, D. Katenkamp, B. Walzel, G. Nöldge, and B. Werner

Subjects
Index (economics), Statistics, Gastroenterology, Surgery, Subject (documents), Mathematics
Published
2000

13. Antiemetic Efficacy of Moderately High-Dose Metoclopramide in Patients Receiving Varying Doses of Cisplatin

Author

Wolfram Domschke, H.J. König, P. Brockmann, S. Domschke, and Ch. Ell

Subjects
Cisplatin, Cancer Research, Chemotherapy, Metoclopramide, business.industry, medicine.drug_class, medicine.medical_treatment, General Medicine, Crossover study, Oncology, Methylprednisolone, Dyskinesia, Anesthesia, Medicine, Antiemetic, In patient, medicine.symptom, business, medicine.drug
Abstract

In 29 patients (48 courses of chemotherapy), a randomized double-blind crossover study was undertaken to establish the antiemetic effectivness of a combination of metoclopramide at a moderately high d

Published
1985

14. Contents, Vol. 42, 1985

Author

N. Nakissa, Louis S. Constine, Wilbert Matthews, P. Rubin, K. Klinga, Manfred Volm, Luigi Di Lauro, Ken Koshiba, Paul H. Sugarbaker, Jürgen Mattern, Veli-Matti Wasenius, Bonaventura Lazzaro, Wolfram Domschke, Joseph P. Fanning, R. Strohl, James M. Slater, P. Brockmann, James D. Kettering, Eiichi Furusawa, Robert Burns, Daila S. Gridley, Masayuki Saito, S. Domschke, Leila Risteli, Juha Risteli, Robert L. Nutter, S. Furusawa, David W. Mantik, Frej Stenbäck, Massimo Lopez, Ch. Ell, H.J. König, Hideki Ohtani, Richard S. Porensky, Delvyn C. Case, Paola Papaldo, and Benno Runnebaum

Subjects
Cancer Research, Oncology, General Medicine
Published
1985

15. Subject Index, Vol. 37, 1987

Author

Giorgio Fiore, W Kohler, K. Ewe, T. Cilluffo, Isto Nordback, Nina Kvist, Peter Skov Olsen, Ossi Teerenhovi, Onofrio G. Manghisi, H. Ruppin, L.I. Larsson, E. Amdrup, Domenico Sansonno, Pekka Vilja, H. Tsukada, A. L. Blum, R. Stoll, Paolo Detomaso, Ossi Auvinen, John Calam, Bronislaw L. Slomiany, Hardy Stern, C. Emde, Amalia Slomiany, P. Delikaris, Joanna C. Bojarski, Timo Koivula, Gaetano Bufano, Steen Seier Poulsen, Lorna A. Meldrum, Maria A. Papanice, T Gasser, Jørgen Hedemark Poulsen, Peter Bauerfeind, Ebba Nexo, J. Sarosiek, Jan Bilski, Aimo Harmoinen, C J Fimmel, and Wolfram Domschke

Subjects
Index (economics), Statistics, Gastroenterology, Subject (documents), Mathematics
Published
1987

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