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Exploring prehistoric variation in human–environmental interaction is critical for understanding the historical patterns and mechanisms of long-term human–land evolution. In this paper we review the published radiocarbon and optically stimulated luminescence (OSL) data from Late Paleolithic, Neolithic and Bronze Age sites in China, analyze the spatial–temporal distribution of these sites, and compare it with the results of recent paleoclimatic and archaeological studies. We seek to study the trajectory and influencing factors of human–environmental interactions in late prehistoric China. We detect changing patterns in the relationship between humans and the environment during different phases of the prehistoric era in China. Climate change clearly affected the environment of hunter-gatherer groups between 50,000–10,000 BP (before present, defined as 1950AD), and variation in human population in Neolithic China (∼10,000–4000 BP) was likely influenced primarily by the development of agriculture, in addition to substantial climate events. The spatial scale of human settlements expanded in the Bronze Age (∼4000–2200 BP) in a period of cooling climate. During this time the impact of human activities on the environment increased significantly, primarily caused by technological innovations related to the onset of prehistoric transcontinental cultural exchange in Eurasia. [ABSTRACT FROM AUTHOR]