1. HLA-DRB1*1501 tagging rs3135388 polymorphism is not associated with neuromyelitis optica.
- Author
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Matiello, Marcelo, Schaefer-Klein, Janet, Brum, Doralina G., Atkinson, Elizabeth J., Kantarci, Orhun H., and Weinshenker, Brian G.
- Subjects
HLA histocompatibility antigens ,GENETIC polymorphisms ,MULTIPLE sclerosis ,NEUROLOGICAL disorders ,CASE-control method - Abstract
Background: Association of the HLA-DRB1*1501 allele with multiple sclerosis is well established, but its association with neuromyelitis optica has only been evaluated in small populations. Methods: We performed a case-control genetic association study to evaluate the association of HLA-DRB1*1501 with neuromyelitis optica. The single nucleotide polymorphism rs3135388, which tags HLA-DRB1*1501, was genotyped in 164 patients with neuromyelitis optica, 220 patients with multiple sclerosis and 959 controls matched for age, gender and ethnicity. Genotyping for rs3135388 was performed by Taqman-based 50 nuclease assay. Results: Rs3135388*A was positively associated with multiple sclerosis (OR=3.93; 95% CI=2.58-5.97, p=1.18 x10
-09 ) but negatively associated with NMO (OR=0.57; 95% CI=0.36-0.91, p=0.01). Conclusions: Multiple sclerosis and neuromyelitis optica differ in their associations with DRB1*1501. [ABSTRACT FROM AUTHOR]- Published
- 2010
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