1. Do Genetic Markers of Inflammation Modify the Relationship between Periodontitis and Nonalcoholic Fatty Liver Disease? Findings from the SHIP Study
- Author
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Julia Mayerle, Aderonke A. Akinkugbe, Gerardo Heiss, Markus M. Lerch, Gary D. Slade, Alfred S. Barritt, Thomas Kocher, M. Nauck, Astrid Petersmann, Birte Holtfreter, Henry Völzke, Steven Offenbacher, Christy L. Avery, and Stephen R. Cole
- Subjects
Adult ,Genetic Markers ,Male ,0301 basic medicine ,medicine.medical_specialty ,Inflammation ,Polymorphism, Single Nucleotide ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,Non-alcoholic Fatty Liver Disease ,Germany ,Surveys and Questionnaires ,Internal medicine ,Epidemiology ,Nonalcoholic fatty liver disease ,Prevalence ,medicine ,Humans ,Periodontitis ,General Dentistry ,biology ,business.industry ,C-reactive protein ,Research Reports ,030206 dentistry ,Middle Aged ,medicine.disease ,Experimental animal ,C-Reactive Protein ,030104 developmental biology ,Genetic marker ,Study of Health in Pomerania ,biology.protein ,Female ,medicine.symptom ,business - Abstract
An association between periodontitis and nonalcoholic fatty liver disease (NAFLD) has been reported by experimental animal and epidemiologic studies. This study investigated whether circulating levels of serum C-reactive protein (CRP) and a weighted genetic CRP score representing markers of inflammatory burden modify the association between periodontitis and NAFLD. Data came from 2,481 participants of the Study of Health in Pomerania who attended baseline examination that occurred between 1997 and 2001. Periodontitis was defined as the percentage of sites (0%, 3 mg/L. Periodontitis was positively associated with higher prevalence odds of NAFLD, and this relationship was modified by serum CRP levels.
- Published
- 2017
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