1. Spinocoumarin I, a New Coumarin Derivative from Astragalus spinosus Forssk
- Author
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Soad M. Toaima, Mohamed M. Radwan, Aya M. Asaad, David G. I. Kingston, and Nadia A. El-Sebakhy
- Subjects
Pharmacology ,Traditional medicine ,010405 organic chemistry ,Plant Science ,General Medicine ,Fabaceae ,Coumarin ,01 natural sciences ,0104 chemical sciences ,Astragalus spinosus ,010404 medicinal & biomolecular chemistry ,chemistry.chemical_compound ,Complementary and alternative medicine ,chemistry ,Phytochemical ,Drug Discovery ,Derivative (chemistry) - Abstract
Phytochemical investigation of the roots of Astragalus spinosus Forssk (Fabaceae) resulted in the isolation of ten metabolites. The structure of spinocoumarin I (1), a new coumarin derivative, was established as 3-[( cis-2′,5′-dihydroxycinnamoyl)]-7-hydroxy-6-methoxycoumarin. The structures of the isolated compounds were determined using spectroscopic methods. All compounds exhibited weak antiproliferative activity against the A2780 ovarian cancer cell line.
- Published
- 2007
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