1. Innate immunity in cardiac myxomas and its pathological and clinical correlations
- Author
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Tullio Barni, Anna Di Vito, Natalia Malara, Stefania Leonetti, Franco Arturi, Eusebio Chiefari, Gabriella Cardillo, Francesco Saverio Brunetti, Gianluca Santise, Chiara Mignogna, Ivan Presta, Daniele Maselli, Domenico Augusto Francesco Maisano, Annalidia Donato, and Giuseppe Donato more...
- Subjects
Adult ,Male ,0301 basic medicine ,Pathology ,medicine.medical_specialty ,Anemia ,Immunology ,Population ,Macrophage polarization ,mast cells ,Cell Count ,Tryptase ,Blood Sedimentation ,Biology ,Microbiology ,Heart Neoplasms ,03 medical and health sciences ,0302 clinical medicine ,Biomarkers, Tumor ,medicine ,Humans ,Macrophage ,Cardiac myxomas ,education ,innate immunity ,Molecular Biology ,Aged ,Retrospective Studies ,education.field_of_study ,medicine.diagnostic_test ,CD68 ,erythrosedimentation rate ,Macrophages ,Original Articles ,Cell Biology ,Middle Aged ,medicine.disease ,Immunohistochemistry ,Immunity, Innate ,030104 developmental biology ,Infectious Diseases ,030220 oncology & carcinogenesis ,Erythrocyte sedimentation rate ,cardiovascular system ,biology.protein ,Female ,Myxoma ,CD163 - Abstract
Cardiac myxomas are the most common benign cardiac tumor. We investigated the immunohistochemical properties of 11 surgically excised cardiac myxomas, in order to analyze the correlation between macrophages and mast cell populations and clinical parameters. CD68+/CD163−/iNOS− (M0) cells represent the most abundant macrophage phenotype; however, CD68+/CD163+ cells (M2) were also frequent. CD68+/iNOS+ (M1) elements were rare. Mast cells, defined as a population of c-kit (CD117)+ and/or tryptase+ cells were also detected. Statistical analysis showed significant correlations between c-kit (CD117)+ and tryptase, CD68 and erythrocyte sedimentation rate (ESR), ESR and red blood cell count (RBC), and prothrombin time and platelet count. The inverse correlation between RBCs in peripheral blood and ESR suggested that anemia associated with chronic inflammatory disease is a noncasual event in patients suffering from cardiac myxoma. Mechanical hemolysis may be only a minor component of anemia, according to the lack of correlation between echographic surface and RBCs. Moreover, tumor size did not correlate with ESR, showing that inflammatory state may depend from both tumor cells population and inflammatory infiltrate. In the future, modulation of macrophage polarization in cardiac myxomas might represent important therapeutic target. more...
- Published
- 2017
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