1. Peroxisome Proliferator-Activated Receptors and Atherosclerosis
- Author
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Božidarka L. Zarić, Srđjan Đ Stojanović, Dimitri P. Mikhailidis, Dragana Nikolic, Esma R. Isenovic, Sanja Soskic, Branislava Dobutovic, Edita Stokic, Milan Obradovic, Emina Sudar, Soskić, S., Dobutović, B., Sudar, E., Obradović, M., Nikolić, D., Zarić, B., Stojanović, S., Stokić, E., Mikhailidis, D., and Isenović, E.
- Subjects
peroxisome proliferator-activated receptors gamma ,Peroxisome proliferator-activated receptor gamma ,medicine.medical_specialty ,Peroxisome Proliferator-Activated Receptors ,peroxisome proliferator-activated receptors alpha ,Inflammation ,atherosclerotic plaque ,030204 cardiovascular system & hematology ,03 medical and health sciences ,atherosclerosi ,0302 clinical medicine ,Internal medicine ,Humans ,Medicine ,Receptor ,Hypolipidemic Agents ,030304 developmental biology ,0303 health sciences ,business.industry ,Fibric Acids ,peroxisome proliferator-activated receptors γ ,Lipid metabolism ,Peroxisome ,Atherosclerosis ,Lipid Metabolism ,peroxisome proliferator-activated receptors α ,3. Good health ,Endocrinology ,Nuclear receptor ,Cancer research ,lipids (amino acids, peptides, and proteins) ,Peroxisome proliferator-activated receptor alpha ,atherosclerosis ,medicine.symptom ,Signal transduction ,Cardiology and Cardiovascular Medicine ,business ,Signal Transduction - Abstract
The peroxisome proliferator-activated receptors (PPARs) represent the family of 3 nuclear receptor isoforms-PPARα, -γ, and -δ/β, which are encoded by different genes. As lipid sensors, they are primarily involved in regulation of lipid metabolism and subsequently in inflammation and atherosclerosis. Atherosclerosis considers accumulation of the cells and extracellular matrix in the vessel wall leading to the formation of atherosclerotic plaque, atherothrombosis, and other vascular complications. Besides existence of natural ligands for PPARs, their more potent synthetic ligands are fibrates and thiazolidindiones. Future investigations should now focus on the mechanisms of PPARs activation, which might present new approaches involved in the antiatherosclerotic effects revealed in this review. In addition, in this review we are presenting latest data from recent performed clinical studies which have focus on novel approach to PPARs agonists as potential therapeutic agents in the treatment of complex disease such as atherosclerosis. © SAGE Publications 2011.
- Published
- 2011
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