1. Effect of diabetes mellitus on the clinical outcome of lower limb arterial bypass surgery: A propensity score analysis
- Author
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Georgios Kouvelos, Evangelos Kontopantelis, Konstantinos G. Moulakakis, Georgios Mantas, Spyros N. Vasdekis, Konstantinos Antonopoulos, George Geroulakos, Andreas M. Lazaris, and Miltiadis Matsagkas
- Subjects
Male ,medicine.medical_specialty ,Time Factors ,Databases, Factual ,Kaplan-Meier Estimate ,030204 cardiovascular system & hematology ,Risk Assessment ,Outcome (game theory) ,Amputation, Surgical ,Disease-Free Survival ,Lower limb ,Peripheral Arterial Disease ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Internal medicine ,Diabetes mellitus ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,030212 general & internal medicine ,Propensity Score ,Vascular Patency ,Aged ,Aged, 80 and over ,business.industry ,General Medicine ,Middle Aged ,Limb Salvage ,medicine.disease ,Surgery ,Logistic Models ,Treatment Outcome ,Lower Extremity ,Bypass surgery ,Propensity score matching ,Cardiology ,Female ,Cardiology and Cardiovascular Medicine ,business ,Vascular Surgical Procedures ,Diabetic Angiopathies - Abstract
Objectives Diabetic patients who undergo lower limb arterial bypass surgery are considered to have a worse clinical outcome compared to non-diabetics. The aim of the study was to test this hypothesis after applying propensity score matching analysis. Patients and methods A total of 113 consecutive lower limb bypass procedures (55 diabetic and 58 non-diabetic) were evaluated regarding their clinical outcome. Endpoints of the study included amputation-free survival, limb salvage, patency and patients’ survival up to 36 months post-procedure. After propensity score matching analysis, two new groups, diabetic and non-diabetic, of 31 limbs in each one were created, both equivalent regarding all baseline characteristics. Results Between the propensity score matching groups, the amputation-free survival was 68.8% in the non-diabetic and 37.7% in the diabetic group at 36 months ( p = 0.004). Similarly, the survival was 88.6% and 57.6%, respectively, in the two groups at the same time point ( p = 0.01). On the contrary, no difference was found in patency (58.3% vs. 56%) and in limb salvage rate (74.1% vs. 60.8%). Conclusions Lower limbs arterial bypass surgery has similar results regarding patency and limb salvage rate in diabetic and non-diabetic patients. On the contrary, mortality is worse in diabetic patients, this affecting negatively their amputation-free survival.
- Published
- 2016
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