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1. Patterns of Immunoreactivity with TTF-1 Antibodies 8G7G3/1 and SPT24 Suggest Distinct Immunoprofiles Between Most Pulmonary and Nonpulmonary Small Cell Carcinomas

Author

Laurence M. Briski, Manju Aron, Jonathan I. Epstein, Daniel H. Russell, Naziheh Assarzadegan, Katiana S. Delma, Henry O’Dell, Estelamari Rodriguez, Elizabeth A. Montgomery, and Oleksandr N. Kryvenko

Subjects
Surgery, Anatomy, Pathology and Forensic Medicine
Abstract

Introduction. Small cell carcinoma can arise from various sites. Herein, we analyze the ability of 2 thyroid transcription factor-1 (TTF-1) antibodies (SPT24 and 8G7G3/1) to separate pulmonary from nonpulmonary small cell carcinoma. Materials and Methods. We analyzed 26 pulmonary and 83 nonpulmonary small cell carcinomas, and 14 Merkel cell carcinomas. Each tumor was stained with SPT24 and 8G7G3/1. Extent of nuclear staining was scored as diffuse (>50%), focal (11%-50%), rare (1%-10%), or negative (

Published
2023

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