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Start Over Descriptor "Hybrid receptors" Publisher sage publications
2 results on '"Hybrid receptors"'

1. Effects of obesity on insulin: insulin-like growth factor 1 hybrid receptor expression and Akt phosphorylation in conduit and resistance arteries

Author

Jesper Worm, Richard M Cubbon, Katherine I Bridge, Grith Skytte-Olsen, Anna Skromna, Rita Slaaby, Romana Mughal, Marianne Schiødt, Gro Klitgaard-Povlsen, Henning Hvid, Nadira Yuldasheva, Mark T. Kearney, Irma Buza, and Natallia Makava

Subjects
Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Receptor expression, 030209 endocrinology & metabolism, 030204 cardiovascular system & hematology, Diet, High-Fat, Receptor, IGF Type 1, 03 medical and health sciences, Insulin-like growth factor, 0302 clinical medicine, Antigens, CD, Internal medicine, Diabetes mellitus, Human Umbilical Vein Endothelial Cells, Internal Medicine, medicine, Animals, Humans, Insulin, Obesity, Insulin-Like Growth Factor I, Phosphorylation, hybrid receptors, Diet, Fat-Restricted, Aorta, Cells, Cultured, IGF-1 receptors, business.industry, Receptors, Somatomedin, Original Articles, medicine.disease, Receptor, Insulin, Mesenteric Arteries, Enzyme Activation, Mice, Inbred C57BL, Vasodilation, Disease Models, Animal, Endocrinology, Vascular Resistance, Akt phosphorylation, Cardiology and Cardiovascular Medicine, business, Proto-Oncogene Proteins c-akt, Signal Transduction
Abstract

Insulin and insulin-like growth factor-1 stimulate specific responses in arteries, which may be disrupted by diet-induced obesity. We examined (1) temporal effects of high-fat diet compared to low-fat diet in mice on insulin receptor, insulin-like growth factor-1 receptor, insulin receptor/insulin-like growth factor-1 receptor hybrid receptor expression and insulin/insulin-like growth factor-1-mediated Akt phosphorylation in aorta; and (2) effects of high-fat diet on insulin and insulin-like growth factor-1-mediated Akt phosphorylation and vascular tone in resistance arteries. Medium-term high-fat diet (5 weeks) decreased insulin-like growth factor-1 receptor expression and increased hybrid expression (~30%) only. After long-term (16 weeks) high-fat diet, insulin receptor expression was reduced by ~30%, insulin-like growth factor-1 receptor expression decreased a further ~40% and hybrid expression increased a further ~60%. Independent correlates of hybrid receptor expression were high-fat diet, duration of high-fat diet and plasma insulin-like growth factor-1 (all p

Published
2018
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2. Effects of obesity on insulin: insulin-like growth factor 1 hybrid receptor expression and Akt phosphorylation in conduit and resistance arteries.

Author

Mughal RS, Bridge K, Buza I, Slaaby R, Worm J, Klitgaard-Povlsen G, Hvid H, Schiødt M, Cubbon R, Yuldasheva N, Skromna A, Makava N, Skytte-Olsen G, and Kearney MT

Subjects
Animals, Antigens, CD metabolism, Aorta enzymology, Cells, Cultured, Diet, Fat-Restricted, Diet, High-Fat, Disease Models, Animal, Enzyme Activation, Human Umbilical Vein Endothelial Cells drug effects, Human Umbilical Vein Endothelial Cells enzymology, Humans, Insulin-Like Growth Factor I pharmacology, Male, Mesenteric Arteries enzymology, Mesenteric Arteries physiopathology, Mice, Inbred C57BL, Obesity blood, Obesity physiopathology, Phosphorylation, Receptor, IGF Type 1 genetics, Receptor, Insulin metabolism, Receptors, Somatomedin metabolism, Signal Transduction drug effects, Vasodilation drug effects, Aorta drug effects, Insulin pharmacology, Mesenteric Arteries drug effects, Obesity enzymology, Proto-Oncogene Proteins c-akt metabolism, Receptor, IGF Type 1 metabolism, Vascular Resistance drug effects
Abstract

Insulin and insulin-like growth factor-1 stimulate specific responses in arteries, which may be disrupted by diet-induced obesity. We examined (1) temporal effects of high-fat diet compared to low-fat diet in mice on insulin receptor, insulin-like growth factor-1 receptor, insulin receptor/insulin-like growth factor-1 receptor hybrid receptor expression and insulin/insulin-like growth factor-1-mediated Akt phosphorylation in aorta; and (2) effects of high-fat diet on insulin and insulin-like growth factor-1-mediated Akt phosphorylation and vascular tone in resistance arteries. Medium-term high-fat diet (5 weeks) decreased insulin-like growth factor-1 receptor expression and increased hybrid expression (~30%) only. After long-term (16 weeks) high-fat diet, insulin receptor expression was reduced by ~30%, insulin-like growth factor-1 receptor expression decreased a further ~40% and hybrid expression increased a further ~60%. Independent correlates of hybrid receptor expression were high-fat diet, duration of high-fat diet and plasma insulin-like growth factor-1 (all p < 0.05). In aorta, insulin was a more potent activator of Akt than insulin-like growth factor-1, whereas in resistance arteries, insulin-like growth factor-1 was more potent than insulin. High-fat diet blunted insulin-mediated vasorelaxation ( p < 0.01) but had no effect on insulin-like growth factor-1-mediated vasorelaxation in resistance arteries. Our findings support the possibility that hybrid receptor level is influenced by nutritional and metabolic cues. Moreover, vessel-dependent effects of insulin and insulin-like growth factor-1 on vascular tone and Akt activation may have implications in treating obesity-related vascular disease.

Published
2019
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