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5 results on '"I. Misselevich"'

1. Osteonecrosis of the Femoral Head of Laboratory Animals: The Lessons Learned from a Comparative Study of Osteonecrosis in Man and Experimental Animals

Author

I. Misselevich and J. H. Boss

Subjects
0301 basic medicine, medicine.medical_specialty, 040301 veterinary sciences, Avascular necrosis, Fibrin, Muscle hypertrophy, Venous stasis, 0403 veterinary science, 03 medical and health sciences, Femoral head, Femur Head Necrosis, medicine, Animals, Humans, Disseminated intravascular coagulation, General Veterinary, biology, business.industry, 04 agricultural and veterinary sciences, Blood flow, medicine.disease, Arterial occlusion, Surgery, Disease Models, Animal, 030104 developmental biology, medicine.anatomical_structure, biology.protein, business
Abstract

Animal models of osteonecrosis of the femoral head are indispensable to the understanding of successful treatment modalities for avascular necrosis of the femoral head in adults and in children with Legg-Calvé-Perthes disease. Many of these models adequately reflect the current “vascular deprivation” theory regarding the etiology of the disease. In addition to spontaneous occurrence, surgical- and corticosteroid-induced models are suitable, common experimental ones. Osteonecrosis of spontaneously hypertensive rats appears to be due to defective bone formation and compression of the arteries entering the femoral head at its lateral facets by daily weight-bearing loads. Successful modeling of surgical-induced femoral capital necrosis can be a challenge in animals with a dual epiphyseal blood supply. High doses of corticosteroids are a pivotal risk factor in the development of osteonecrosis. The pathogenesis of corticosteroid-induced osteonecrosis likely resides in reduced blood flow. Steroids may reduce blood flow by numerous mechanisms, including marrow adipocytic hypertrophy leading to sinusoidal compression, venous stasis and, eventually, obstruction of the arteries, and arterial occlusion by fat emboli and lipid-loaded fibrin-platelet thrombi. Other, less common varieties of osteonecrosis include those secondary to endotoxin-induced disseminated intravascular coagulation, immune reactions, immoderately low or high temperatures, and high-impact-related injuries. Common to these diverse forms of osteonecrosis are fibrin thrombi clogging arterioles and small arteries.

Published
2003
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2. Angiolymphomatoid Hyperplasia with Eosinophilia of the Oral Mucous Membrane

Author

I. Misselevich, Milo Fradis, Jochanan H. Boss, and Ludwig Podoshin

Subjects
Pathology, medicine.medical_specialty, business.industry, Oral mucous membrane, Nodule (medicine), Hyperplasia, medicine.disease, Hemangioma, Lesion, Otorhinolaryngology, medicine, Eosinophilia, medicine.symptom, business, Angiolymphoid hyperplasia with eosinophilia, Histological examination
Abstract

A 59-year-old patient is reported with a protruding, mucosal nodule within the mandibular alveolar fold. Histological examination of the excised mass disclosed angiolymphoid hyperplasia with eosinophilia (histiocytoid hemangioma). Though the lesion was not completely excised and invaded the adjacent muscle of the floor of the mouth, there was no recurrence during a follow-up period of 17 months.

Published
1995
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3. Squamous cell carcinoma of the lung presenting with cutaneous leukocytoclastic vasculitis: a case report.

Author

Odeh M, Misselevich I, and Oliven A

Subjects
Aged, Carcinoma, Squamous Cell complications, Humans, Lung Neoplasms complications, Male, Carcinoma, Squamous Cell diagnosis, Lung Neoplasms diagnosis, Paraneoplastic Syndromes, Skin Diseases etiology, Vasculitis, Leukocytoclastic, Cutaneous etiology
Abstract

An elderly patient with paraneoplastic cutaneous leukocytoclastic vasculitis (CLV) leading to the discovery of an as-yet asymptomatic, potentially surgically curable squamous cell carcinoma of the lung is presented. This type of vasculitis has not been previously described in association with this type of lung cancer. Since vasculitic paraneoplastic syndromes, including CLV, may develop before the clinical presentation of malignant tumors, the present case and others previously reported strongly suggest that in apparently idiopathic CLV, patients should be evaluated for the presence of occult malignancy that could be curable by early detection.

Published
2001
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4. Severe reversible cardiomyopathy associated with systemic vasculitis in primary Sjögren's syndrome.

Author

Golan TD, Keren D, Elias N, Naschitz JE, Toubi E, Misselevich I, and Yeshurun D

Subjects
Adult, Cardiomyopathies diagnosis, Cardiomyopathies therapy, Female, Humans, Vasculitis diagnosis, Vasculitis therapy, Cardiomyopathies etiology, Sjogren's Syndrome complications, Vasculitis etiology
Abstract

A 40y old woman with primary Sjögren's syndrome developed elevated purpura, peripheral neuropathy, muscular tenderness, abdominal pain, heart failure, and convulsive spells. The hallmarks of this disease were high titers of anti-Ro antibodies and low complement levels in the serum, leukocytoclastic small vessel vasculitis in the cutaneous biopsy specimen, and a life threatening clinical course. Echocardiography revealed left ventricular hypokinesis with low ejection fraction, which is unlike the more common features of cardiomyopathy complicating Sjögren's syndrome. The rapidly deteriorating heart failure and other systemic complications remitted on pulse corticosteroid and cyclophosphamide therapy. The pathogenesis of heart failure, which appeared concurrently with vasculitis and was reversed on immunosuppressive therapy, is explained in the context of the systemic disease. Leukocytoclastic vasculitis might be at the origin of this rare variant of acute, severe but reversible cardiomyopathy in pSS.

Published
1997
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5. Angiolymphomatoid hyperplasia with eosinophilia of the oral mucous membrane.

Author

Misselevich I, Podoshin L, Fradis M, and Boss JH

Subjects
Angiolymphoid Hyperplasia with Eosinophilia surgery, Humans, Male, Middle Aged, Mouth Mucosa surgery, Angiolymphoid Hyperplasia with Eosinophilia pathology, Mouth Mucosa pathology
Abstract

A 59-year-old patient is reported with a protruding, mucosal nodule within the mandibular alveolar fold. Histological examination of the excised mass disclosed angiolymphoid hyperplasia with eosinophilia (histiocytoid hemangioma). Though the lesion was not completely excised and invaded the adjacent muscle of the floor of the mouth, there was no recurrence during a follow-up period of 17 months.

Published
1995

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