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Start Over Author "Jiao-Lan Qin" Publisher sage publications
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1. Water Soluble Copper(II) and Zinc(II) Complexes of Mangiferin: Synthesis, Antitumour Activity and DNA Binding Studies

Author

Yan-Cheng Liu, Ying-Bo Li, Jiao-Lan Qin, Yun-Liang Zhang, Deng Shengping, Tao Yuan, Zhen-Feng Chen, and Hong-Hua Han

Subjects
010405 organic chemistry, chemistry.chemical_element, General Chemistry, Zinc, 010402 general chemistry, 01 natural sciences, Copper, 0104 chemical sciences, chemistry.chemical_compound, Water soluble, chemistry, Organic chemistry, Mangiferin, DNA
Abstract

The reactions of mangiferin (H-MF) with Cu(II) and Zn(II) yielded [Cu(MF)(OH)(H2O)]x5H2O and [Zn(MF)(OH)(H2O)]x4H2O. The MTT assay against four tumour cell lines revealed that the Cu complex generally showed higher in vitro cytotoxicity vs. free H-MF than the Zn complex, which may be due to the different bioactivities of Cu(II) and Zn(II). DNA binding studies of both complexes vs. H-MF indicated that they tended to bind intercalatively with DNA. Both complexes also exhibited topoisomerase I inhibition at 100 μM, which could be due to their DNA binding affinities.

Published
2016
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