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6 results on '"Lien MY"'

1. Subclinical Atherosclerosis, Endothelial Function, and Serum Inflammatory Markers in Chronic Kidney Disease Stages 3 to 4

Author

Stefan Agewall, Olof Heimbürger, Shirin Ghanavatian, Lien My Diep, Peter Stenvinkel, Astrid Seeberger, Peter Bárány, and Morteza Rohani

Subjects
Male, medicine.medical_specialty, Brachial Artery, Renal function, Inflammation, Kidney, Severity of Illness Index, Gastroenterology, Sex Factors, Predictive Value of Tests, Risk Factors, Internal medicine, medicine.artery, medicine, Humans, Renal Insufficiency, Chronic, Brachial artery, Interleukin 6, Aged, Ultrasonography, biology, business.industry, Age Factors, Case-control study, Middle Aged, Atherosclerosis, medicine.disease, Up-Regulation, Vasodilation, medicine.anatomical_structure, Intima-media thickness, Case-Control Studies, Asymptomatic Diseases, biology.protein, Female, Endothelium, Vascular, Inflammation Mediators, medicine.symptom, Cardiology and Cardiovascular Medicine, business, Biomarkers, Glomerular Filtration Rate, Kidney disease
Abstract

Different inflammatory markers, brachial artery flow-mediated dilatation (FMD), and brachial intima-media thickness (bIMT) were measured in 50 patients with chronic kidney disease (CKD) stages 3 to 4 with estimated glomerular filtration rate (eGFR) and 35 age- and gender-matched controls. The bIMT was significantly increased in the patients with CKD compared with controls (0.43 mm [0.42, 0.45] vs 0.34 mm [0.32, 0.36]; P < .001). There was no significant difference in FMD between the study groups (4.7% vs 5.3%; P = .56). There were significant correlations between bIMT and high-sensitive C-reactive protein, vascular cellular adhesion molecule 1, tumor necrosis factor, and interleukin 6 ( P < .05). However, eGFR adjusted for age and gender was the best predictor of bIMT. In conclusion, bIMT and inflammatory markers were increased in patients with CKD compared with the controls. Furthermore, significant correlations between bIMT and inflammatory activity in patients with CKD were observed. The eGFR adjusted for age and gender was the best predictor of bIMT.

Published
2013
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6. The Associations Between Pre- and Postnatal Maternal Symptoms of Distress and Preschooler's Symptoms of ADHD, Oppositional Defiant Disorder, Conduct Disorder, and Anxiety.

Author

Bendiksen B, Aase H, Diep LM, Svensson E, Friis S, and Zeiner P

Subjects
Anxiety, Attention Deficit and Disruptive Behavior Disorders, Child, Preschool, Cohort Studies, Comorbidity, Female, Humans, Male, Norway, Pregnancy, Attention Deficit Disorder with Hyperactivity epidemiology, Conduct Disorder epidemiology
Abstract

Objective: The objective of this article is to examine the associations between pre- and postnatal maternal distress and preschooler's symptoms of ADHD, Oppositional Defiant Disorder (ODD), Conduct Disorder (CD), and anxiety, by timing and gender. Method: Children, aged 3.5 years ( N = 1,195), recruited from the Norwegian Mother and Child Cohort Study, were assessed with a semistructured parental psychiatric interview. Perinatal maternal symptoms of distress were assessed by Symptom Checklist (SCL-5); Poisson regression was used to examine the associations. Results: Mid-gestational maternal distress significantly increased the average number of child symptoms, ranging between 3.8% for ADHD hyperactive-impulsive (ADHD-HI) and 8.7% for anxiety. The combination of high maternal scores of distress both pre- and postnatally were associated with increased risk of child symptoms of anxiety (relative risk [RR] = 2.10; 95% confidence interval [CI] = [1.43, 3.07]), CD (RR = 1.83; 95% CI = [1.33, 2.51]), and ODD (RR = 1.30; 95% CI = [1.03, 1.64]), with minor sex differences. Conclusion: Maternal distress during mid-gestation was associated with ADHD, behavioral, and emotional symptoms in preschool children. Continued exposure into the postnatal period may further increase these risk associations .

Published
2020
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