1. Phycobiliproteins and phycocyanin of Arthrospira maxima (Spirulina) reduce apoptosis promoters and glomerular dysfunction in mercury-related acute kidney injury
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María Estela Meléndez Camargo, Vanessa Blas-Valdivia, Edgar Cano-Europa, Margarita Franco-Colín, María Mirian Estévez Carmona, Placido Rojas-Franco, and María del Rocío Elizabeth Ortíz-Butrón
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biology ,Chemistry ,Phycobiliprotein ,030232 urology & nephrology ,Acute kidney injury ,chemistry.chemical_element ,010501 environmental sciences ,medicine.disease ,biology.organism_classification ,01 natural sciences ,Mercury (element) ,03 medical and health sciences ,0302 clinical medicine ,Nutraceutical ,Functional food ,Apoptosis ,Phycocyanin ,medicine ,Food science ,Arthrospira ,0105 earth and related environmental sciences - Abstract
Arthrospira maxima ( Spirulina) is considered a nutraceutical or functional food because it provides health benefits and it is used as nephroprotector because it contains nucleophilic compounds as phycobiliproteins and phycocyanin that prevent oxidative stress and cellular damage process. Also, it is known that inorganic mercury is bioaccumulated and exerted kidney toxicity. Despite the nephroprotective effect of Spirulina and its components, there is not enough information about the effect of them on renal function as well as the apoptosis process inhibition. This work aimed to investigate whether phycobiliproteins and phycocyanin of Spirulina can improve HgCl2-related glomerular and tubular renal dysfunction as well as the Bax, Bcl2, and effectors caspases alterations. Male mice were administrated with Spirulina, phycobiliproteins or phycocyanin 30 min before 5 mg/Kg HgCl2 administration. The nutraceuticals were administrated for the next 5 days. Then, the mice were euthanized. The renal function, caspases 3 and 9 activities, as well as Bax and Bcl2 expression were evaluated. Spirulina and its components prevent HgCl2-related apoptosis induction and glomerular dysfunction. We concluded that phycobiliproteins and phycocyanin of Spirulina reduce glomerular damage but not the tubular dysfunction in a mercury-related acute kidney injury. more...
- Published
- 2018
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