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1. Acute Renal Failure Related to High Doses of Acyclovir (15 mg/kg/8 h) during Treatment of Varicella Zoster Virus Encephalitis

Author

Martin Martinot, Martine Tebacher-Alt, Samira Fafi-Kremer, Mahsa Mohseni-Zadeh, Monica Groza, Alexandre Klein, and Karine Demesmay

Subjects
Male, Herpesvirus 3, Human, viruses, Acyclovir, 030312 virology, medicine.disease_cause, Antiviral Agents, 03 medical and health sciences, medicine, High doses, Humans, Pharmacology (medical), Aged, Encephalitis, Varicella Zoster, Pharmacology, 0303 health sciences, integumentary system, business.industry, Varicella zoster virus, virus diseases, Electroencephalography, Acute Kidney Injury, Middle Aged, biochemical phenomena, metabolism, and nutrition, medicine.disease, Magnetic Resonance Imaging, Virology, Regimen, Infectious Diseases, Herpes simplex virus, Female, business, Biomarkers, Encephalitis
Abstract

Varicella zoster virus (VZV) is less susceptible than herpes simplex virus to acyclovir. The optimal acyclovir regimen during VZV encephalitis remains unknown. We report two cases of acute renal failure after an increase in acyclovir dosage from 10 mg to 15 mg/kg/8 h during the treatment of VZV encephalitis according to French guidelines.

Published
2018

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