1. Endobronchial Pagetoid Spread of a Breast Carcinoma Metastatic to the Lung
- Author
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Paola Baccarini, Maria C. Cucchi, Nicola Lacava, Maria Pia Foschini, Melissa A. T. Monica, Monica, Melissa A. T., Baccarini, Paola, Cucchi, Maria C., Lacava, Nicola, and Foschini, Maria P.
- Subjects
Pathology ,medicine.medical_specialty ,HER-2 amplification ,Bronchi ,Pathology and Forensic Medicine ,030207 dermatology & venereal diseases ,03 medical and health sciences ,breast cancer ,0302 clinical medicine ,Breast cancer ,Biomarkers, Tumor ,Medicine ,Lobar Bronchus ,Aged ,Neoplasm Invasivene ,Lung ,endobronchial pagetoid spread ,business.industry ,Carcinoma, Ductal, Breast ,Histology ,respiratory system ,medicine.disease ,Immunohistochemistry ,Primary tumor ,Metastatic breast cancer ,Lung Neoplasm ,medicine.anatomical_structure ,030220 oncology & carcinogenesis ,Pagetoid ,Female ,Surgery ,metastatic breast cancer ,Anatomy ,business ,Breast carcinoma ,Breast Neoplasm ,Human - Abstract
A case of endobronchial pagetoid spread of a breast carcinoma metastatic to the lung is described. A 73-year-old woman underwent wedge lung resection after the cytological diagnosis of lung metastasis from ductal invasive breast carcinoma. The breast carcinoma had been surgically removed 6 years previously; at the time of diagnosis it was a T1N0, grade 3 invasive ductal carcinoma, with HER-2 amplification. The lung metastasis measured 1,9 cm and showed the same histology and biological profile of the primary tumor. In addition, numerous neoplastic cells, with large cytoplasm and atypical nuclei, appear to spread along the mucosa of the bronchi adjacent to the metastatic lesion as well as that of the main lobar bronchus, intermingled with the columnar ciliated cells. The neoplastic elements were negative for TTF-1 and strongly HER-2 positive; these features appeared consistent with endobronchial pagetoid spread by the metastatic breast carcinomatous cells.
- Published
- 2016
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