1. Efficacy, safety and tolerability of tesaglitazar when added to the therapeutic regimen of poorly controlled insulin-treated patients with type 2 diabetes
- Author
-
Shamik Parikh, Conrad Tou, and Robert E Ratner
- Subjects
Blood Glucose ,Male ,Time Factors ,Apolipoprotein B ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Type 2 diabetes ,030204 cardiovascular system & hematology ,chemistry.chemical_compound ,0302 clinical medicine ,Insulin ,Aged, 80 and over ,Phenylpropionates ,biology ,Middle Aged ,Tolerability ,Drug Therapy, Combination ,Female ,Cardiology and Cardiovascular Medicine ,Adult ,Alkanesulfonates ,Agonist ,medicine.medical_specialty ,Tesaglitazar ,medicine.drug_class ,030209 endocrinology & metabolism ,Placebo ,03 medical and health sciences ,Double-Blind Method ,Diabetes mellitus ,Internal medicine ,Internal Medicine ,medicine ,Humans ,Hypoglycemic Agents ,PPAR alpha ,Triglycerides ,Aged ,Glycated Hemoglobin ,Dose-Response Relationship, Drug ,business.industry ,Cholesterol, HDL ,medicine.disease ,PPAR gamma ,Endocrinology ,Diabetes Mellitus, Type 2 ,chemistry ,biology.protein ,business - Abstract
This randomised, double-blind, parallel-group study assessed the effects of addition of the dual peroxisome proliferator-activated receptor (PPAR) α/γ agonist, tesaglitazar, for 24 weeks to the therapeutic regimen of 392 poorly controlled (glycosylated haemoglobin [HbA1C] 7.5-10%) insulin-treated, type 2 diabetes patients. At 24 weeks, tesaglitazar 0.5 mg resulted in a 0.66% (95% confidence intervals: −0.85, −0.47; p The clinical development of tesaglitazar is no longer continuing; its effects on the glucose and lipid abnormalities of type 2 diabetes suggest that the concept of dual PPARα/γ agonism is worthy of further investigation.
- Published
- 2007
- Full Text
- View/download PDF